<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15307
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSEEDFSRSLLLSAGKNTPTVSLNYLLEIAIQQVFHEITILSELLGKKQDNEKKISLVQFAHSTRMLFVKLLALVKWVKTSKKFESCTSICCLLDQQSQLFVQTADTLAKYTTVDLLLARLPMFQGHFPRLPQCIKEAFVKKKNINKRDQARVLHRLNTVIERRIAKLASEFSPRIKQISIKNGLTIVVPGEFEFQVAVFGEAETERWLLLNVNMLVDDYEIGFGVDLIHPSQMLLVHQVLQSRINEAQNPIADAYKFLHYYALSAQLDILFCQLTSLISNGRFRDNVIIERYNETEHFLLLGYWIKKPKMRIAVPGVKPVPQYRLQVSFNPRDPDGGLLIRHFPSATGISNFDIGKGQMRIEHVLAETFIIRCKERLLRIRKNLEAEHPKAYIAQTGDTSPTLTLLLCDDEMSCPEEHLVIAVNMFTGRVICSVTCLNVSQRATLRELEKALYDNYNQDTIKRCLNRLKIMVMIERYRRSVTTLQIRIVSENQMLPCLQKVRPIPKDKICLQFIKEEEYYLIITFTAESFSYLQINIYLLWSTDERTQMIEIQPTNRIFSVSYSRLARRNEANVDNIPPVRPIKGSYRDLTCAIASVEERILLKRLGEQLKNKGIPHDLVNQEDAVGGLVVHIKNAQTLIGAHSADFFGNVGRCCLRIDNRVRTSWPLECCMHNIPLVADVDPNRKNPTSCTWVQDVSISGLNPAAGASDSIGDQILDRLDKYCSMYNIVRKFAVAYDKYYRNYTSIEAFTFHKLLLLYGDERDQLMILSFRPKKTTNERFGLNFGQTTPRRILSKVGPMNMNLENRWNPHGLLTSILKDKYELSFRFRENLIFSRLNREGDLIGLVQYLISTSSTLDCLVHFSRVRYQSYKYLPYMTGNEIQFPLKLKSSLHPVTDTDIRLTFGHLNLAILLLSDGAIGIRDASLAKPQVAGLKEFFNLMSGGQTEEMMDDDEQPSTSTGKHASSSPTHPKSLPPPVVCASPQIGSSKSVPPPTGLSTSPAPTRESKELKATYSTLYVDQATLKRACHFEKNACGLYVSPLDDFLSALVYIHRITYALKSVFTSKAPSMITNCQIEESRPDSVGFLQMFNDLNIFQLTLTFSTILKLSTVRCVLFIDPATMKIRLTLEYKGESSPSDESVAVFTDFFERIVYRLNNELAFVAFLNMCKATPTLFESFVAIIKEQQFGLTCPCSVSLNLVYTTSTKDTINKRNNFSGVLIDQNSNQVLIVVRRIFLSKHFQ |
Length | 1242 |
Position | Tail |
Organism | Diploscapter pachys |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.128 |
Instability index | 41.21 |
Isoelectric point | 8.90 |
Molecular weight | 141429.16 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15307
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 172.33| 53| 88| 191| 251| 1
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191- 251 (78.94/74.45) GEFEFQVAVFGEAETERWLLLnvNMLVDDYEIGFGVDLIHPsqmllVHQV.LQSRINeAQNP
282- 335 (93.39/63.35) GRFRDNVIIERYNETEHFLLL..GYWIKKPKMRIAVPGVKP.....VPQYrLQVSFN.PRDP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.05| 13| 89| 1097| 1109| 4
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1097- 1109 (21.94/10.73) FQLTLTFSTILKL
1188- 1200 (23.12/11.67) FGLTCPCSVSLNL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 205.68| 68| 561| 27| 108| 7
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27- 97 (104.81/108.37) LEIAIQQVfhEITILSELLGKKQDNeKKI..SLVQFAHSTRMLFVKLLALVKWVKT.SKKFESCTSICCL.LDQQ
591- 662 (100.86/68.94) LTCAIASV..EERILLKRLGEQLKN.KGIphDLVNQEDAVGGLVVHIKNAQTLIGAhSADFFGNVGRCCLrIDNR
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