<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15303

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSEEDFSRSLLLSAGKNTPTVSLNYLLEIAIQQVFHEITILSELLGKKQDNEKKISLVQFAHSTRMLFVKLLALVKWVKTSKKFESCTSICCLLDQQSQLFVQTADTLAKYTTVDLLLARLPMFQGHFPRLPQCIKEAFVKKKNINKRDQARVLHRLNTVIERRIAKLASEFSPRIKQISIKNGLTIVVPGEFEFQVAVFGEAETERWLLLNVNMLVDDYEIGFGVDLIHPSQMLLVHQVLQSRINEAQNPIADAYKFLHYYALSAQLDILFCQLTSLISNGRFRDNVIIERYNETEHFLLLGYWIKKPKMRIAVPGVKPVPQYRLQVSFNPRDPDGGLLIRHFPSATGISNFDIGKGQMRIEHVLAETFIIRCKERLLRIRKNLEAEHPKAYIAQTGDTSPTLTLLLCDDEMSCPEEHLVIAVNMFTGRVICSVTCLNVSQRATLRELEKALYDNYNQDTIKRCLNRLKIMVMIERYRRSVTTLQIRIVSENQMLPCLQKVRPIPKDKICLQFIKEEEYYLIITFTAESFSYLQINIYLLWSTDERTQMIEIQPTNRIFSVSYSRLARRNEANVDNIPPVRPIKGSYRDLTCAIASVEERILLKRLGEQLKNKGIPHDLVNQEDAVGGLVVHIKNAQTLIGAHSADFFGNVGRCCLRIDNRVRTSWPLECCMHNIPLVADVDPNRKNPTSCTWVQDVSISGLNPAAGASDSIGDQILDRLDKYCSMYNIVRKFAVAYDKYYRNYTSIEAFTFHKLLLLYGDERDQLMILSFRPKKTTNERFGLNFGQTTPRRILSKVGPMNMNLENRWNPHGLLTSILKDKYELSFRFRENLIFSRLNREGDLIGLVQYLISTSSTLDCLVHFSRVRYQSYKYLPYMTGNEIQFPLKLKSSLHPVTDTDIRLTFGHLNLAILLLSDGAIGIRDASLAKPQVAGLKEFFNLMSGGQTEEMMDDDEQPSTSTGKHASSSPTHPKSLPPPVVCASPQIGSSKSVPPPTGLSTSPAPTRESKELKATYSTLYVDQATLKRACHFEKNACGLYVSPLDDFLSALVYIHRITYALKSVFTSKAPSMITNCQIEESRPDSVGFLQMFNDLNIFQLTLTFSTILKLSTVRCVLFIDPATMKIRLTLEYSNSLMFWRSIEFCAFRRRIVPE
Length1153
PositionTail
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.09
Grand average of hydropathy-0.148
Instability index44.20
Isoelectric point8.97
Molecular weight131582.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15303
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.74|      21|      88|     191|     211|       1
---------------------------------------------------------------------------
  191-  211 (37.81/23.50)	GEFEFQVAVFGEAETERWLLL
  282-  302 (37.93/23.60)	GRFRDNVIIERYNETEHFLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     400.38|     128|     561|     325|     465|       2
---------------------------------------------------------------------------
  325-  465 (204.57/168.76)	RLQVSFNP.RDPDGGLLIRHF........PSATGISNFDIGKGQMrieHVLAETFIIRCKERLLRIRKnlEAEHPKAYIAQTGDTSPTltlllcdDEMSCPEEHLVIAVNMFTGRVICSVTCLNVSQrATLRELE..KALYDN.Y.NQDTIKR.C
  888- 1029 (195.81/130.88)	KLKSSLHPvTDTDIRLTFGHLnlailllsDGAIGIRDASLAKPQV...AGLKEFFNLMSGGQTEEMMD..DDEQPSTSTGKHASSSPT.......HPKSLPPPVVCASPQIGSSKSVPPPTGLSTSP.APTRESKelKATYSTlYvDQATLKRaC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.68|      68|     561|      27|     108|       3
---------------------------------------------------------------------------
   27-   97 (104.81/112.12)	LEIAIQQVfhEITILSELLGKKQDNeKKI..SLVQFAHSTRMLFVKLLALVKWVKT.SKKFESCTSICCL.LDQQ
  591-  662 (100.86/71.34)	LTCAIASV..EERILLKRLGEQLKN.KGIphDLVNQEDAVGGLVVHIKNAQTLIGAhSADFFGNVGRCCLrIDNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.68|      72|     219|     493|     570|       4
---------------------------------------------------------------------------
  493-  570 (112.82/87.89)	NQMLPCLQKVRPIpkDKICLQF.IKEEEYYLIITfTAESFSYLQIniyLLWSTDERTQM..IEIQP...TNRIFSVSYSRLARR
  715-  792 (114.86/70.84)	DQILDRLDKYCSM..YNIVRKFaVAYDKYYRNYT.SIEAFTFHKL...LLLYGDERDQLmiLSFRPkktTNERFGLNFGQTTPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.47|      13|     124|     677|     689|       6
---------------------------------------------------------------------------
  677-  689 (24.14/16.06)	PLVADVDPNRKNP
  693-  705 (24.33/16.24)	TWVQDVSISGLNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15303 with Med14 domain of Kingdom Metazoa
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