<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15285

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMSELSLRDNMSECVDDIENIVKQIMDSLLNHRHQKSSESLTNLVKLFDTKQADLRQLLGKVEQFHERASLTRELEGCVKERDELINEVLTNLQGAELALTSTVFQANRKLKLVREAEARPVNSEAIIKVAHQISKGSSVAAPFNWQIGDPSRPFPTEPEFRESSLMTGRQTAHPTSQSYSLARQFANTQIRTPPQMGRPGGMPSPMLTQQKGLSPSKGFPGAVASPRSGQITRIPSGSLPGKTPPIQQTTPGQAQIKRPAQVFFFIIDLFEMFFLTLEPPHLISKHQYRKWSGPLGF
Length297
PositionMiddle
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.06
Grand average of hydropathy-0.474
Instability index47.91
Isoelectric point9.39
Molecular weight33140.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15285
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.09|      40|      40|     130|     169|       1
---------------------------------------------------------------------------
  130-  157 (45.92/27.77)	..............AHQI.....SKG..SSVAAPF.NWQIGD.PSRPFPTE
  158-  198 (59.74/38.45)	PEFRESSLMTGRqtAHPT.....SQS..YSLARQFaNTQIRT.P..PQMGR
  199-  242 (50.43/31.26)	PGGMPSPMLTQQ......kglspSKGfpGAVASPR.SGQITRiPSGSLPGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.81|      17|      22|       7|      26|       2
---------------------------------------------------------------------------
    7-   26 (20.41/28.53)	RDNMSEcvDDIENIVKqIMD
   32-   48 (28.41/21.13)	RHQKSS..ESLTNLVK.LFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.42|      23|      40|      52|      75|       3
---------------------------------------------------------------------------
   52-   75 (33.44/28.32)	ADLrQLLGKVEQFHERASLTRELE
   95-  117 (35.98/25.04)	AEL.ALTSTVFQANRKLKLVREAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15285 with Med4 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NWQIGDPSRPFPTEPEFRESSLMTGRQTAHPTSQSYSLARQFANTQIRTPPQMGRPGGMPSPMLTQQKGLSPSKGFPGAVASPRSGQITRIPSGSLPGKTPPIQQTTPGQA
144
254










Molecular Recognition Features






MoRF SequenceStartStop




NANANA