<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15279

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTINAQRQPTLIRINKMHVNCGRRVPVLLAPWSLKGTLLPLTEKANMKMDEHNEYKEWNKFIPLEISQLEGDLQTDEDMPRMVAVEIDSIRMFYPSCLICVTLDEDGHCHSVNNPNDILPNLTPSELIVQETHAPLSMNSMSSQVLPPRIVISKRNKLLTAGGEALWSSKGLAQVTRYTVNQQNSIRRPYHERTKKNKKSESGINRTEPMPSSLESDCMSDEEKEPVVDWATCQTGDLQTGMYCSADEAMVYHYDPNNQTLPLTDDETFVCSPFTPVRTISPCVNCTWPAAPASQMVSSVFNEIFWENDDTQQLPSHTSLERKAAAADYYYNPTLPSLWEQPHYATYHNRRQNEKRRANYPPAIRFDELSPEEPGSQETIPATTSPLPEDDARRTVGREPSLLMDSIRNVTGNAKRAAASGAPEAKRRRIVKKKKKRMDNKELNWPSIEDLDIEDISHDTEEDFFCKVHFDTGRDSPDSEHSEPASPVVEEPPQNADCEEDIDDGGEGCSSISGGDMIVPMDVDEAPASTQPADSILSPPASNETPEQGNHHWNRVGTPSVGENTNYTSWQPRLAQADAHSMNQIYPTPPSVQSEAQQFSPASVPPPQQTMAHMPPCSQLYQTENDEVTEPVELVNAQEEEELSEEELPLLPINDPIKFFIDKKGPIAGILQKIERRPIHGVRENVRLPIVTRFSSKYRLSGKGAAVLPQPLDYQKMISRSEKNNSPNVQPTEHQRFFDESITVTFPDERMPGTPTQLQAMAMQYNFRPPYMTQLSTTMAPPTPQSIHPHHPGLPPNHPMQSQFMHPQMQMRMGPMGAQTPPHAAFGPPHGYMHNQGIQGMYAMQLGAGNQMSHYGGMQAPQNLNSQMQPPLYSSSSVPMRSTGFHQNGPMAPPYARQPSIIDLTGPMSGASTSNAPFQNINQHQQTTPQFPVSHHTPQTMHMVPSSSMHQRRELVPEGSSIVLALVLSDTILDLHFDTVFDACPICSCHTSIRARELGMYITPPEILRQPADQQLIGPWSGFAQQEASTPCTCGFSAVRHRYLSVCSGLFPEDAREATALDSAALSHVPSIQLDSAALVPATNISWFNPENDVHLNIVNQIRILSQTHNWGKAIHHLGSLTEQMSKALKPQEAISSDTGGNADYIVSLVDQTELLLLGNAAMELVTINMLGNRRNTNPSPNFLTYFHPWGLQIANEIREPSVSEWKYLLDNILNSVDKSMKAVRCAGSQEMGKIVEGPLTWRQFVTKNQKTTKDGAAEDELFMQEPIPYILASTDKDAIRIAPQAVQMWENLSLGPYDQPKDVLYVAVTVDCKEAVDSTKTYLENISQLYERMRLGRHVACPTGECRDGVLKSVSNPTKNKFTASPQTIDFQDMAKYVDNKNFMIKLKNFVQSMEESLAQLLIEEERLFDRGYFRELLALDWRAKRNASAALAANAEKKYYERENQKPEEMGTSSHQPPTPLQPQLNLAPQLTPAVSIGSPTCLQQLIEQPSTLLPSIGGSSTQMLPPQQSARDDSATAIEPEDIPTDDYPALPHVIVIYVVNPFTFGHEFRHPMMMRLSMLAITRAFNAVCSRLPLSHRIQLQLEIVGIEQMGDLIRPFPDYANDPRIPFDLHCRPFNNRHHVKGCDMSDSYRATCLSVYTHPRVLSPDAIRRVQARCMTRFGPGSWMLDSLDALMNMDKSMLFKMPSNAISLAPGPVLYQKDDEKVVQICQEEQILYVSYCLIGGDWLCATVTDGLGRITDSCIINTKPKVDGKPYRNKTQILDTMGRLWTYILSVLSMETRNWRLVIGRLGRMGHGEFRAWTHLLNKASLRRYSARLKEICTACNQMPSSAYTPAIVSACLVTTEAEPNLRVFHDLVEQEAAQEKSKTRKLSTPYDVSVTHIMTYQVGVELILENQEQTGQADEEWFDINIEDPEMDIIINDIGTSTGPQPSAGFKQGGPPTFFPEQSQDITAENQPLASGYYISTAPAGDLPEWFWANCPSARRRTPVHLKASLHINVPEVQKGDDIGLTKDKTETKDKNELSSEKHPLDSAKTDEVLRHVLETYNALSWLNVNASTGERVSCLPMHIQHLTRLYHTVARFLL
Length2088
PositionMiddle
OrganismDiploscapter pachys
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Diploscapter.
Aromaticity0.07
Grand average of hydropathy-0.512
Instability index59.56
Isoelectric point5.50
Molecular weight233839.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15279
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.11|      26|      26|     865|     890|       1
---------------------------------------------------------------------------
  865-  890 (51.43/24.24)	NSQMQ..PPLYSSSSV.....P..MR...STGFHQNGP
  892-  917 (25.21/ 8.00)	....A..PPYARQPSIidltgP..M....SGASTSNAP
  922-  951 (24.47/ 7.54)	NQHQQttPQFPVSHHT.....PqtMHmvpSSSMHQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     373.79|      89|     761|     698|     786|       2
---------------------------------------------------------------------------
  112-  148 (27.05/ 7.88)	..............................VN.....................NPNDILPNlTPSEL...IVQETHAPLSMNSMSSQVL..PP....................................................
  535-  619 (67.39/33.04)	.SILSPPASNETPE.QGNHHwNRVGTPSVGENtnytswqprlaqadahsmnqiYP.......TPPSVQSEAQQ..FSPASVPPPQQTMAhmPPCSQ.................................................
  640-  714 (104.43/56.15)	EEELSEEELPLLPINDPIKF...FIDKKGPIA.....................GILQKIER.RPIH....GVRENVRLPIVTRFSSK....................................yrLSGKGAAVLPQ.....PLDY
  715-  832 (144.41/81.08)	QKMISRSEKNNSPNVQPTEH.QRFFDESITVT.....................FPDERMPG.TPTQLQAMAMQYNFRPPYMTQLSTTMA..PPTPQSihphhpglppnhpmqsqfmhpqmqMR..MGPMGAQTPPHaafgpPHGY
 1480- 1514 (30.51/10.04)	............................................................G.SPTCLQQLIEQPSTLLPSIGGSSTQML..PP.QQS........................AR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.44|      32|     132|      30|      80|       3
---------------------------------------------------------------------------
   43-   76 (51.23/56.84)	EKANMKMDehNEYKEWNKFIPLEISQLEGDLQTD
  432-  463 (55.21/20.25)	KKKKKRMD..NKELNWPSIEDLDIEDISHDTEED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.99|      26|     761|    1247|    1276|       4
---------------------------------------------------------------------------
 1247- 1276 (37.01/31.53)	TKNQKTTKDgaaEDELfMQEPIPYILASTD
 2015- 2040 (44.98/24.93)	TKDKTETKD...KNEL.SSEKHPLDSAKTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     230.28|      88|     761|     968|    1101|       5
---------------------------------------------------------------------------
  973- 1101 (117.34/146.45)	LDLHFDTVFDACPI..CSCHTSIRARELGMYiTPPEILRQPA......................................................................................................................................dqqligpwsgfaqqeastpctcgfsavrHRYlsvcSGLFPEDAREATALDSAAlsHVPSIQldSAALVPATNiswfNPENDVHLNIVNQ
 1612- 1652 (45.53/ 6.42)	FDLHCRPFNNRHHVkgCDMSDSYRATCLSVY.THPRVLSPDA...............................................................................................................................................................................................................................
 1815- 1863 (67.41/25.26)	..........................................irrvqarcmtrfgpgswmldsldalmnmdksmlfkmpsnaislapgpvlyqkddekvvqicqeeqilyvsycliggdwlcatvtdglgritdsciintkpkvdgkpyrnktqildtmgrlwtyilsvlsmetrnwrlvigrlgrmghgefrawthllnkaslRRY....SARLKEICTACNQMPSSA..YTPAIV..SACLVTTEA....EPNLRVFHDLVEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.32|      15|      32|     382|     396|       6
---------------------------------------------------------------------------
  382-  396 (26.89/16.06)	ATTSPLPEDDARRTV
  417-  431 (25.43/14.73)	AAASGAPEAKRRRIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.35|      24|      25|     251|     274|      12
---------------------------------------------------------------------------
  251-  274 (46.58/28.28)	VYHYDPN.NQTLPLTDDETFVCSPF
  277-  301 (41.77/24.49)	VRTISPCvNCTWPAAPASQMVSSVF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15279 with Med13 domain of Kingdom Metazoa
Unable to open file!