<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15204

Description Mediator of RNA polymerase II transcription subunit 17
SequencePARPGLVRSTTTELPRSKPSPSYLSSLRSARRPIPPAAAHRRQPPTHLPLSAPESASRPKHHPAQSIEPFARSLLPHQSRSEGQQTAAMGDDLRLDLDKLPIKRLEAIDEAGNEHYPPDTSSEEQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAQKAWPWQGLHESLQLAQQELTVVLDLISTVEANDTVAVATISKPRPLPDEVLVDTAVSAATKLQRLRHLGRYFKQSAKTMQQQFQKESRFYGSLIRLQQNWKVKRQRGNAPGINSFMFDVVDTSQLDTAAMPRMSSLSLVPIDQDSSGTLSVQVPQKSCRFLSLQFRGDSANGPESYACRTKGVSSTTSSAAEDDALEDDDVNKSVKQAHSILRNIHKSIFEEQVLDMVIRETFVQTQGVNVTGMREDFLQLAIGEESLLCLSLVNSGQDSDSEIAGHEEHNNSEANLVLATTNGKQEPLKMDTSGFLNPKSLEIYLLHLFHENILRKVREKYRNIVRYQSPAQTAESAGEDCGLLSHFCMTVAHKTFSKKVQLELESVVSRVPYLQLRSLPTWHSRTSSWSLCLRVPQPILAADRPMKPSDNGEPKYKSSRTQFNTKIVLKDGQISLLGEGSPSIAGSLTTKPSDGYLINSYNCDLEDLPTMVLQQVASQIINWLHEEALVLGMSVTRDFLCLYFDLEHGDTLGLVAHVDPDDEYGCISWYLTVDHPAEEDGKAPAADDPWAEKRRFLGYLSLEVLYSTLLDLINLCGTGARPVR
Length751
PositionHead
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.06
Grand average of hydropathy-0.442
Instability index55.56
Isoelectric point6.07
Molecular weight83500.34
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP15204
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.03|      96|     179|     417|     520|       1
---------------------------------------------------------------------------
  417-  520 (141.00/103.33)	LSLVnsGQDSDSeIAGHEEHNNSEANLVlATTNGKQE..P...LKMDTSGFLNPKSLEIYLLHLfheNILRKVREKYRNIVRYQSPAQTAESAGED.CGLLSHFcMTVAH
  601-  702 (157.03/89.01)	ISLL..GEGSPS.IAGSLTTKPSDGYLI.NSYNCDLEdlPtmvLQQVASQIINWLHEEALVLGM...SVTRDFLCLYFDLEHGDTLGLVAHVDPDDeYGCISWY.LTVDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.11|      17|      23|      14|      33|       2
---------------------------------------------------------------------------
   16-   33 (26.35/16.24)	RSKPsPSY..LSSLRSARRP
   41-   59 (26.76/ 7.26)	RRQP.PTHlpLSAPESASRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.42|      26|     250|     280|     337|       4
---------------------------------------------------------------------------
  301-  337 (39.90/78.21)	SSGTLSVQVPQ.........KScrflslqfrgdSANG.PESYACRTK
  554-  589 (39.52/13.22)	SSWSLCLRVPQpilaadrpmKP...........SDNGePKYKSSRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.07|      35|     555|     143|     182|       5
---------------------------------------------------------------------------
  143-  182 (52.85/46.86)	AKKAKKAAAEDAaqkawPWQGLHESLQ.LAQQEL.TVVLDLI
  704-  740 (51.22/32.81)	AEEDGKAPAADD.....PWAEKRRFLGyLSLEVLySTLLDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15204 with Med17 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PARPGLVRSTTTELPRSKPSPSYLSSLRSARRPIPPAAAHRRQPPTHLPLSAPESASRPKHHPAQSIEPFARSLLPHQSRSEGQQTAAMGDDLRL
1
95










Molecular Recognition Features






MoRF SequenceStartStop




1) SYLSSLRSARRPIPPAAAHRRQP
22
44