<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15112

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQPAVAKLRVVSSGLWVAPGNSEEIAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSASSLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKELDSVNDPHLGADGQQKLERADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFYGSSRGLGVNSNFLRLRRQRNSSSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACRQSDLPLNNDIAGSKMVSKRSRSEITEVSSHAGKEVRENMQGTNGQGGCSWGWSEEGVVMDINILLSEFGDFSDFFQEDELDFGEPPGTAESHTLVTPASEYGDMAFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASSAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCESPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESVGDKSEKSDKLIPANLSRDAGRSNLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLSLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESGSNSDLVPKYDVKRKESIPARLSSDVDHEMYDRSRMENVGVWRSVVVPKGAKPLDCLSANTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYLPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARVIKDIKLTSNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLQKPNELAALKDIAFTVYNKARRIPRFVSTSDLFQSHSYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAAGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDAMESSRFGADASSSRVYSSISGGTDSGASPLLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIHDRNMPSSPSMLYNPHSKSSFTKGQPGNKKQILVEQTGMESSRGSLHFVRSISLVAVSQDSSLHLACQADLPATRPTSTSGEGNQSSSNTSSSASYLDGFAPVKSIGSMSASSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPAVRKKLTKEDSRHSVLSVSIVDYYGGTTVQDKMSRGSKQAARHETSAARDYETDMHNVLEAVAAELHSLSWMTASPVFMERRSALPFHCDMVLRLRRLLHYADRHLSQSTEKGDVS
Length1803
PositionKinase
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.07
Grand average of hydropathy-0.298
Instability index59.54
Isoelectric point5.89
Molecular weight196203.44
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP15112
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     362.74|     111|     120|     895|    1010|       1
---------------------------------------------------------------------------
  895- 1010 (185.40/98.54)	DWCRGRSNIAESAAMGdAYSFHYTTGDIRETSNS.IPIGGDAMSPPQSSSDRGTseeHHKGYHRVRPTIAVLpSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAK.PVT.YYALCP
 1021- 1134 (177.34/82.58)	DFFMQLGTIYEVCKLG.THSPQHSGGQIEQSPGKyLPSGLVLVECPDQLKSSGS...HSVSISSVTEYFQAL.SKSWSVKSFLSSLARVIKDIKLTSNISTNQKESSNiPCTvVYVVCP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     452.64|     109|     267|     271|     382|       2
---------------------------------------------------------------------------
  271-  382 (168.87/87.25)	SPSSYFRNSSFYGS.SRG.LGVNSNFLRLRRQRNSSSNGMASSISSVSSTSNGSEHAVAAkggDLLADADSTAC........RQSDLPLNN.DIAGSKMVSKRSRS.EITEVSSHAGKEVRENM
  396-  496 (146.47/69.61)	SEEGVVMDINILLS.E...FGDFSDFFQEDELDFGEPPGTAESHTLVTPASEYGDMA........FIDSPSVAM........DIPEQRLSPvGFTSMEAFNHQTMS.PIQDVASKVQEPLKE..
  539-  652 (137.30/64.81)	SPATLFTNPYLPGSkKRGsCGFSS...RVYSYDVTQS....SKVESVGDKSEKSDKLIPA...NLSRDAGRSNLytlvqgrkKESEKSLNNaDEQSCKGETSRPVSgETSFSSSLSLQKKSDNM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.77|      61|     279|    1247|    1310|       4
---------------------------------------------------------------------------
 1247- 1310 (105.73/68.76)	SHSYMSRPQSTMMHT.ASPGPTlwKECLApRMSGQTLSRET.EF..DASMRSVSWDNSWQPGRAAGLP
 1528- 1592 (95.05/51.43)	SPSMLYNPHSKSSFTkGQPGNK..KQILV.EQTGMESSRGSlHFvrSISLVAVSQDSSLHLACQADLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.34|      97|     712|      58|     162|       5
---------------------------------------------------------------------------
   58-  162 (154.72/109.81)	NPPTRNQNSFRRaQPTVEFVFA....ATEEAIFVHVIISARYMRN....LSSDDIEKV.LTHTPRSVGEGLpvivapSGMLG..RLVGCCPSDLARQVySSKLSASSLPGFTQPTI
  769-  876 (148.62/86.46)	NTFTGTSPSVQR.QPIVELLSAmallVQQSTSFVDIALDMDDGDGsffwLSLDEQRRRgFSCDPSMVHAGC......GGLLGtcHSKDCAGVDLVDPL.SAEVSESSMIGLLQSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.61|      19|     769|     716|     734|       6
---------------------------------------------------------------------------
  716-  734 (32.85/20.54)	VPKYDVKRKESIPARLSSD
 1488- 1506 (35.76/23.08)	VKKWPVQLRRSIPDGIPSN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15112 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPDGIPSNSNGPTLEQQDMGLIHDRNMPSSPSMLYNPHSKSSFTKGQPGNKKQILVEQT
1499
1557










Molecular Recognition Features






MoRF SequenceStartStop




1) QEDELDF
419
425