<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15101

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSASSLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKELDSVNDPHLGADGQQKLERADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFYGSSRGLGVNSNFLRLRRQRNSSSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACRQSDLPLNNDIAGSKMVSKRSRSEITEVSSHAGKEVRENMQGTNGQGGCSWGWSEEGVVMDINILLSEFGDFSDFFQEDELDFGEPPGTAESHTLVTPASEYGDMAFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASSAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCESPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESVGDKSEKSDKLIPANLSRDAGRSNLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLSLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESGSNSDLVPKYDVKRKESIPARLSSDVDHEMYDRSRMENVGVWRSVVVPKGAKPLDCLSANTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYLPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARVIKDIKLTSNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLQKPNELAALKDIAFTVYNKARRIPRFVSTSDLFQSHSYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAAGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDAMESSRFGADASSSRVYSSISGGTDSGASPLLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIHDRNMPSSPSMLYNPHSKSSFTKGQPGNKKQILVEQTGMESSRGSLHFVRSISLVAVSQDSSLHLACQADLPATRPTSTSGEGNQSSSNTSSSASYLDGFAPVKSIGSMSASSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPAVRKKLTKEDSRHSVLSVSIVDYYGGTTVQDKMSRGSKQAARHETSAARDYETDMHNVLEAVAAELHSLSWMTASPVFMERRSALPFHCDMVLRLRRLLHYADRHLSQSTEKGDVS
Length1708
PositionKinase
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.07
Grand average of hydropathy-0.314
Instability index59.95
Isoelectric point5.74
Molecular weight185677.53
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15101
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     473.13|     164|     996|      71|     303|       2
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   82-  287 (240.72/241.25)	GFppASTDKISESENNQIKKELDSVNDP..HLGAD.GQQKL....ERADGLPVLERTFIYPPE..AVMVPMVHqafvrfsskrmwsqdwmgsssweawpfwnfSPSSYFRNSSFYGS.SRG.LGVNSnflRLRRQRNSSSngmaSSISSVSSTSNGSEHAVAAkggDLLADADSTAC........RQSDLPLNN.DIAGSKMVSKRSRS.EITEVSSHAGKEVRENM
  373-  557 (232.41/117.47)	GF..TSMEAFNHQTMSPIQDVASKVQEPlkEIASSaGSQSLvlssSRSDFLTRAEATLTFAPEyaAVEISSCE..............................SPATLFTNPYLPGSkKRGsCGFSS...RVYSYDVTQS....SKVESVGDKSEKSDKLIPA...NLSRDAGRSNLytlvqgrkKESEKSLNNaDEQSCKGETSRPVSgETSFSSSLSLQKKSDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.90|      36|      87|     851|     887|       3
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   14-   44 (33.21/15.23)	.THTPRSVG...EGLPVIVAPSGMLgrLVgCCPSD.....
  851-  887 (58.38/38.89)	GTSEEHHKGYHRVRPTIAVLPSPSL..LV.GYQDDwLKTS
  941-  976 (67.32/39.43)	GTHSPQHSGGQIEQSPGKYLPSGLV..LV.ECPDQ.LKSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.28|      19|      82|     669|     692|       4
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  672-  690 (33.48/28.10)	SANTFTGTSPSVQRQPIVE
 1442- 1460 (32.80/10.94)	SKSSFTKGQPGNKKQILVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     330.35|     104|     211|    1251|    1363|       6
---------------------------------------------------------------------------
 1251- 1363 (172.31/104.77)	MESSRfgadaSSSRVYSSISGGTDSGASPLLEGSEND.SGTSLHCCYGWTEDwrwlVCIWTDSRGELLDSL..IFPFGGISSRQDTTV....LQSLFIQILQ.QGCQIMSSSPEASNTRSR
 1464- 1575 (158.04/79.25)	MESSR.....GSLHFVRSISLVAVSQDSSLHLACQADlPATRPTSTSGEGNQ....SSSNTSSSASYLDGFapVKSIGSMSASSYLLVpspsMRYLSPATLQlPTCLTSESPPLAHLLHSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.24|      15|     191|    1206|    1227|       7
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 1213- 1227 (29.53/25.30)	GLPDPSKIPELCAQD
 1407- 1421 (28.71/ 8.46)	GIPSNSNGPTLEQQD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.55|      41|      66|     984|    1029|      11
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  984- 1029 (54.94/48.60)	SSVTeYFQALSKSWSVKSFLssLARVIKDikLTSNISTNQKESSNI
 1053- 1093 (65.61/40.21)	SSVA.LGSILSSERERKSFL..YTQVAKA..LNSSASADEASASNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.96|      13|     769|     621|     633|      12
---------------------------------------------------------------------------
  621-  633 (23.88/13.72)	VPKYDVKRKESIP
 1393- 1405 (25.08/14.78)	VKKWPVQLRRSIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15101 with Med13 domain of Kingdom Viridiplantae
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