<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15094

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASSAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCESPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESVGDKSEKSDKLIPANLSRDAGRSNLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLSLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESGSNSDLVPKYDVKRKESIPARLSSDVDHEMYDRSRMENVGVWRSVVVPKGAKPLDCLSANTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYLPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARVIKDIKLTSNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLQKPNELAALKDIAFTVYNKARRIPRFVSTSDLFQSHSYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAAGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDAMESSRFGADASSSRVYSSISGGTDSGASPLLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIHDRNMPSSPSMLYNPHSKSSFTKGQPGNKKQILVEQTGMESSRGSLHFVRSISLVAVSQDSSLHLACQADLPATRPTSTSGEGNQSSSNTSSSASYLDGFAPVKSIGSMSASSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPAVRKKLTKEDSRHSVLSVSIVDYYGGTTVQDKMSRGSKQAARHETSAARDYETDMHNVLEAVAAELHSLSWMTASPVFMERRSALPFHCDMVLRLRRLLHYADRHLSQSTEKGDVS
Length1357
PositionKinase
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.07
Grand average of hydropathy-0.279
Instability index61.21
Isoelectric point6.06
Molecular weight147515.70
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP15094
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.51|      53|     185|     809|     876|       1
---------------------------------------------------------------------------
  809-  864 (89.87/80.34)	QSTMMHT.ASPGPTlwKECLApRMSGQTLSRET.EF..DASMRSVSWDNSWQPGRAAGLP
 1090- 1146 (78.64/39.48)	HSKSSFTkGQPGNK..KQILV.EQTGMESSRGSlHFvrSISLVAVSQDSSLHLACQADLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     313.38|      87|     185|       6|      97|       2
---------------------------------------------------------------------------
    6-   97 (131.41/84.87)	SPSVAMDIP....EQRLSPVGF..TS.ME.AFNHQTMS.PIQDVASKVQEPLKEIASS....AGSQslVLSSSRSDFLT.......RAEATLTFAPEYaavEISSCE.......S.PATL
  101-  192 (70.44/36.01)	........PylpgSKKRGSCGF..SSrVY.SYDVTQSS.KVESVGDKSEKSDKLIPANlsrdAG.........RSNLYTlvqgrkkESEKSLNNADE......QSCKgetsrpvS.GETS
  194-  285 (111.53/61.54)	SSSLSLQKK....SDNMLNVGYflLS.MKtALATEIECiTFQAAMCRIRHTLVSLRTK....ASAE..LKSALSSAMQT.......ESGSNSDLVPKY...DVKRKE.......SiPARL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     259.98|      72|     311|     550|     655|       3
---------------------------------------------------------------------------
  500-  538 (34.31/21.47)	...............................GTSEEH.....HKGYHRVRPTIAVLPSPSLLVGYQDDwLKTSAN............
  560-  639 (115.47/85.41)	YALCPDIDM.LTSAATdffMQLGTiyevCkLGTHSPQ.....HSGGQIEQSPGKYLPSGLVLVECPDQ.LKSSGSHSVSISSVTEYF
 1188- 1265 (110.21/46.07)	YLLVPSPSMrYLSPAT...LQLPT....C.LTSESPPlahllHSKGTATPLAMGYVVSKAVPAVRKKL.TKEDSRHSVLSVSIVDYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.65|      55|     191|     674|     733|       6
---------------------------------------------------------------------------
  674-  733 (88.99/60.61)	ESSNIP..CTV...VYVVCP...FPEPSAV.LQTL.VESSVALGSILSSERerksfLYTQVAKALNSSAS
  738-  766 (24.73/ 7.44)	SASN..........VVMLSG...FSIPKLV.LQIVtVETLLRL...........................
  867-  927 (65.94/35.69)	..SKIPelCAQddrKYAFEPlfiLAEPGAVdYNDA.MESS.RFGADASSSR.....VYSSISGGTDSGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.33|      47|      83|     318|     370|       7
---------------------------------------------------------------------------
  318-  370 (70.62/51.95)	DCLSANTFTGTSPSVQRQPIVELLSAmALLVQQSTSFVDIaldmdDGDGSFF.W
  403-  450 (74.71/40.59)	DCAGVDLVDPLSAEVSESSMIGLLQS.DIKSALKTAFANM.....DGPLSVIdW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15094 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPDGIPSNSNGPTLEQQDMGLIHDRNMPSSPSMLYNPHSKSSFTKGQPGNKKQILVEQT
1053
1111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA