<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15011

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSNISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHELSISLAMDTIIRQANVLRHGRWKEAISSERISDSTIGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDFSPFIKIEAGQDMQIKCQHSSFILDPLTDKEARLSLDLCCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDVGAAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPPALLDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYHLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDIGQMEKIKYEKNSNSFDAKLHSLQSIENCDNMMDNELLIQNSVDPLPLLPACSPSFSSLVDETFECEHGSSLPSASPVRSLSLGPQGISTRAISPMQDGALSHAQANNTSIVRPGVGVNSYFPTSLRHLQSTNAFSSSNPVRNSSAIKLSNSKSNHDLSSLSSPSEHGIADGNKPFQLAPSSMLPAHLVRSSPAIEGLGKAITVGSDCAPRKRPLSDFLLDLPSLQGLKSSEPNKRRKISESAKSSLTLQAYSSSSQSGTSLTHGNILAERSNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMDSCAIPYVEEVGMRSPSSNLWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVDADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGIKSQSVNKGHNDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMSKQTNNVPSQGPLANGSSATTMHHASAPSNGTAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPIANRLNATPGGAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRAESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWDRCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1741
PositionTail
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.07
Grand average of hydropathy-0.191
Instability index50.30
Isoelectric point8.37
Molecular weight190091.62
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15011
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      15|      17|    1196|    1212|       1
---------------------------------------------------------------------------
 1196- 1212 (24.19/16.72)	TMHHASAPSngTAHLGG
 1214- 1228 (25.96/11.55)	TLHTAAMLS..AAGRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.01|      11|      19|    1161|    1173|       2
---------------------------------------------------------------------------
 1161- 1173 (16.47/11.79)	PARMPvtVSTGYS
 1183- 1193 (20.53/ 8.84)	PSQGP..LANGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.35|     126|     253|     257|     393|       4
---------------------------------------------------------------------------
  184-  254 (51.65/23.92)	.....................................................SNISVTDGIA..VFRV..DGEFKvllTLGYR...GNLDLWrilhmelL....VGEKNGPIK..LGE...IRRFALGDDIERRMAVSE.............................
  257-  393 (203.50/154.50)	FSVL..YAILHEL..SISLAMDTIIRQAnvlrHGRWK..EAI.SSeriSD...STIGQTGNAA..VMQLGQDGEFD...SSGFRlPVLKLNYW.......L....DGKNSGPAESDFSP...FIKIEAGQDMQIKCQHSSFILDpltDKEARL.SLDLC..CIDVEKLI
  508-  645 (149.21/92.42)	FSSLrtRSILHLLvsTGSFFGLKVYEQS....QGTLKipEAIlHG...SDlmvMGFPQCANAYhlLMQLDKD..F........R.PVFHL..........LetqsDASNKFNANIDAKEamrVNKIDIGQMEKIKYEKNSNSFD...AKLHSLqSIENCdnMMDNELLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.92|      25|      28|     768|     794|       5
---------------------------------------------------------------------------
  768-  794 (43.61/29.21)	SSPSEHGIadGNKPFQLAPSSMLPAHL
 1372- 1396 (44.32/23.80)	SSGLASGI..GGASVRLTPGTGLPVHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      19|      23|    1413|    1432|       6
---------------------------------------------------------------------------
 1413- 1432 (31.90/26.92)	Y.GGGWV....PlAALKKVLRGILK
 1433- 1456 (25.20/15.10)	YlGVLWLfaqlP.ELLKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.36|      23|      23|     939|     961|       7
---------------------------------------------------------------------------
  939-  961 (43.64/25.96)	DDSWKHICLRLGKAGSMSWDVRI
  963-  985 (43.72/26.03)	DPHFKELWELNGGSTSTPWGVGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.30|      21|      21|     817|     837|       9
---------------------------------------------------------------------------
  817-  837 (34.73/22.59)	RKRPLSDFLLDLPSLQGLKSS
  841-  861 (32.57/20.66)	KRRKISESAKSSLTLQAYSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.11|      13|      16|    1322|    1337|      12
---------------------------------------------------------------------------
 1322- 1334 (24.12/ 7.81)	HLNTSAGAPQSAP
 1338- 1350 (23.99/16.59)	RLNATPGGAMSRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.10|      15|      18|    1006|    1020|      16
---------------------------------------------------------------------------
 1006- 1020 (24.02/16.24)	LTYSTVDADSVKRLV
 1026- 1040 (25.08/17.31)	LANARVFARGMRRLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15011 with Med14 domain of Kingdom Viridiplantae
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