<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14915

Description Mediator of RNA polymerase II transcription subunit 13
SequenceYFISCLQGELQTVSWFQFLPIEPDYSATSDRSSKAEQKDALNNTVLSAYLRLQSEGLLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSDLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKEFDSGKDPHLGDDGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMSSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNNNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEVSSHAGNEVRENMQGTNGQGGCSWGWGEEGVVMDINILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEFGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFNHETMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKETIPARLSSDVDHDMYDRSLLENVGVWRSVVVPKGAKPLDSLSAKTFTGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDIDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTSGDIRDTSNSIPIGGDAMSPPQSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSADCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIDQSPGKYLPSGLVLVDCPDQLKTSGSHSVSISSVTEYFQALSKSWSVKSFISSLARIIKDIKLTLNISTNQKESSNMPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSVPKFVLQIVTVETLLRLHKPNELAAFKDIAFTIYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAAGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGSDSGASPLLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLVFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRMNAAQLTKEDRHSVLSVSIVDYYGGGTATVQEKMSRGVGGSTTSKQARNISHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYTERRSALPFHCDMVLRLRRLLHYADRHLSQLTVKGEM
Length1904
PositionKinase
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.08
Grand average of hydropathy-0.297
Instability index58.71
Isoelectric point5.65
Molecular weight207642.14
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14915
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     748.38|     247|     275|    1122|    1395|       1
---------------------------------------------------------------------------
 1122- 1395 (369.84/220.87)	QLGTiyevcKLGTHSPQHSGGQIDQSPGKYLPSGLVL......VDCPDQLKTSgSHSVSISSVTEYFQALSKSWSVKSFIssLARIIKDIKLTLNISTNQKES.SNMPC........TVVYVVCPFPEPSAVLQTLVESSVALgSILSsererksflytQVAKALNSSASADEASASNVVM..LSGF...SVPKFVLQIVTV........ETLLRLHKPNELAAFKDiAFTIYNKARRIprfVSTSDMFQSPTYMSRPQSTMMHT.ASPGPtlwKECLVPRMSGQTLSRETEF...DASMRSVSWD
 1399- 1677 (378.54/177.82)	QPGR.....AAGLPDPSKIPELCAQDDRKYAFEPLFIlaepgaVDYNDTMESS.RFGVDASSSRAYSSISGGSDSGASPL..LEGSENDSGTSLHCCYGWTEDwRWLVCiwtdsrgeLLDSLVFPFGGISSRQDTKVLQSLFI.QILQ...........QGCQIMSSSPEASNTRSRDVIItrIGGFlelEIQEWQKAIYSFggnevkkwPVQLRRSIPDGIPSNSN.GPTLQQQDMGL...IQDRNMPSSPSTLYSPHSKSSFTkGQPGN...KKQILAEQTGMDSSRGSLHlvrSISLVAVSQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.60|      33|      34|     683|     715|       2
---------------------------------------------------------------------------
  636-  679 (29.43/12.97)	...TPATLFTNpylpgskkrgsC.GFSSrvySYDVTQSSKVESAGDKS
  683-  715 (53.51/30.18)	DKLTPANLSRD...........V.GRSS...LYTLVQGRKNESEKSLN
  719-  751 (44.67/23.86)	EQSCKGETSRP...........VsGETS...FSSSLTIQK.KSDSMLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.86|      23|     122|      96|     163|       3
---------------------------------------------------------------------------
   96-  118 (42.55/83.17)	PEMTQPAVAKLRVVSSDLWVAPG
  252-  274 (44.31/ 8.17)	PGFTQPTICQLRGQSYYVEVALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.10|      22|      54|     336|     357|       5
---------------------------------------------------------------------------
  336-  357 (42.05/24.72)	VHQAFVRFSSKRMWSQDWMSSS
  387-  408 (38.05/21.65)	VNSNFLRLRRQRNNNSNGMASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.68|      52|      54|     499|     551|       6
---------------------------------------------------------------------------
  499-  551 (87.96/56.19)	MDI.NILLSEFGdFSDF..FQEDELDFGEPPGTAESHALVTPASEFGDMPFIDSPS
  554-  608 (78.71/45.53)	MDIpEQRLSPVG.FTSMeaFNHETMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14915 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPDGIPSNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQT
2) KISESENNQIKKEFDSGKDPHLGDDGQQKLE
3) RSEITEVSSHAGNEVRENMQGTNGQGGCSW
1596
282
461
1654
312
490










Molecular Recognition Features






MoRF SequenceStartStop




NANANA