<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14851
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | VPLLYYCQQLASTLSSHETCFTQTGDSLFFMHEGLQHARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERMPTLKKLSTLVRAKLLETLVPKEISEVLVADGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGEKTGPIKLEETRRYVLGDDIERRMAVADNPFTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGLKIPGLKVNYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEALILKAIACNIHTRLLEIQRELKKNTQISRSPSDVVLKQKEVHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKRSITPPEVFVSLKTRSILHLLAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWGTNVYYLLMQLDDNLMPVFYLLEVHTDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECSANLLDVEKLQVWRISPLYALKFHLESDIFQSSC |
Length | 574 |
Position | Tail |
Organism | Hordeum vulgare subsp. vulgare (Domesticated barley) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade>
Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.145 |
Instability index | 51.08 |
Isoelectric point | 5.68 |
Molecular weight | 64719.56 |
Publications | PubMed=23075845
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14851
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 173.07| 60| 212| 289| 359| 1
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289- 359 (83.95/80.04) FVLDPLTDKEADLSLD..........LSCIDVEALILKAIACNihTRLLEIQRelkknTQISR.SPsdvvLKQKEVHM..DVLQ
499- 571 (89.12/57.99) YLLEVHTDGEDRSNIDtttdakevvrFNRIDIGQMQLGEDECS..ANLLDVEK.....LQVWRiSP....LYALKFHLesDIFQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 121.83| 38| 59| 367| 406| 5
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367- 406 (62.83/48.14) FENCCTNEVLQVRAYGKSYihLGINIRS.GGFLLQSPKNIL
429- 467 (59.00/38.38) FVSLKTRSILHLLAATGRF..LGLKVYSeCQITLKIPKSIL
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