<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14848

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHEGLQHARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERMPTLKKLSTLVRAKLLETLVPKEISEVLVADGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGEKTGPIKLEETRRYVLGDDIERRMAVADNPFTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGLKIPGLKVNYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEALILKAIACNIHTRLLEIQRELKKNTQISRSPSDVVLKQKEVHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKRSITPPEVFVSLKTRSILHLLAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWGTNVYYLLMQLDDNLMPVFYLLEVHTDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECSANLLDVEKLQVLQSKLNQQSMEDRSPRQSGIDESLPLKHSFSSVVNTVLGYEQDSPSKENRLPYSSPSIHLSPQEVGHQGDSSRAGPPELDDDLLRSNTDTAKLASGVTLDSYLLSNSKSAFSTDTTSSDPAGDPSKLSACESAHDLSLENISTLRSEVPSRKRYLSEFLLNIPSLQRSIIDGGPRKRRKLLEDASNVQSRTTLTYGTILKEGNCCITENIYASVLLQVIKHCSLCIKYAQLTTQMNSLDIPYVEEVGLGTPSSSLWLRLPFAQDGSWKHTCLRLGKAGSMSWSVRINDPYYGALWKLHGGSNTTEWGSVRIANTCEMDSHIYFDYDGIILTYNSVEADSIQRLVLELRRLLNARVFACGMRRLIRVNVDEKLVENQVARRAKLHSARKGFRNRLSDQTAKTFRINAVGLMNLWFSYGANAMTMVHFVVEWEADKVGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTTGPLLSLGGAIRPSKMPTVSGSAQKQNNVLLANGSSPTTVHINSHDAQTSSMLSAVGRTGPGLVPSSLMPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNTLEPSFLSARHTSPNTSSGSQHVVTAANRSSGGPPGEIKLTSGVGCQIAASVSRASNAILPSGFASRTDGAPAHLSLDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQFRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLHLQVLNVKRFHHQQQQQQVPQSSAQGELTPSEIHEICDYFSRCVACEPYDASRIASFIMLLTLPILVIQEFVKLIAWNKSLSEAHGDIATAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHVRTSGGAAWLPFCVSLRLRYTFGDTSHVTYLAMDGSHGGRSCWLQHVDWERCKQSVVKAVNTVNGSPIAGDTAQGRLQMVTEMVQKQLQLCLVYLRDGSLSAGSTRP
Length1565
PositionTail
OrganismHordeum vulgare subsp. vulgare (Domesticated barley)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum.
Aromaticity0.07
Grand average of hydropathy-0.204
Instability index50.09
Isoelectric point6.87
Molecular weight173327.70
Publications
PubMed=23075845

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14848
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.91|      72|     401|    1052|    1131|       1
---------------------------------------------------------------------------
 1052- 1131 (119.32/84.19)	RTGPGlvpSSLMPFDVSVVLRGPY..WIRIIYrnkFSVDmRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPfIMEHVAQG
 1460- 1533 (129.59/69.64)	RTSGG...AAWLPFCVSLRLRYTFgdTSHVTY...LAMD.GSHGGRSCWLQHVDWERCKQSVVKAVNTVNGSP.IAGDTAQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     283.18|      83|     232|     268|     392|       2
---------------------------------------------------------------------------
  268-  358 (128.05/85.23)	EADLS.......LDLSCIDVEAliLKAIACNIHTR.......LLEIQRELKKNTQISRSPSD......VVLKQ..KEVHMDV..LQKR.......VDRRGFENCCTNEvlqvraYGKSYIHL
  507-  582 (98.46/47.91)	EDECS.......ANL..LDVEK..LQVL..................QSKLNQQSMEDRSPRQsgidesLPLKHsfSSVVNTV..LGYE.......QDSPSKENRLP........YSSPSIHL
  646-  730 (56.66/54.27)	PSKLSacesahdLSLENIS.......TLRSEVPSRkrylsefLLNI.......PSLQRSIID.....gGPRKR..RKLLEDAsnVQSRttltygtILKEG..NCCITE..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.96|      11|      17|     596|     606|       5
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  596-  606 (20.39/13.00)	AGPPELDDDLL
  616-  626 (18.57/11.08)	ASGVTLDSYLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14848 with Med14 domain of Kingdom Viridiplantae
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