Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | KPIYKPQVRYAPSLPQKEYCLPKKTRKNSLLAGQSSSPSPYPSRRRRRRPAGSMDAMEEDTPPAPPLPPPPTRGAKQPPYKDPDDGRQRFLLELEFIQCLANPIYINYLAQNRYFEDEAFIGYLKYLKYWQRPEYIKYIMYPHCLFFLELLQNANFRNAMAHPASKEVAHRQQYFFWKNYRNNRLKHILPRPPPEPTPAPAPAPVPTPPPVPAAPSSLPTMSAVGASAMPPMQFIGTPGTNNPKNDMRNVMGGRKRKMG |
Length | 259 |
Position | Middle |
Organism | Hordeum vulgare subsp. vulgare (Domesticated barley) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum. |
Aromaticity | 0.11 |
Grand average of hydropathy | -0.807 |
Instability index | 74.86 |
Isoelectric point | 9.98 |
Molecular weight | 29630.95 |
Publications | PubMed=23075845 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP14818 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.68| 26| 58| 90| 115| 4 --------------------------------------------------------------------------- 90- 115 (47.55/29.89) FLLEL....EFIQCLANPIYINYLAQNRYF 146- 175 (42.13/25.77) FFLELlqnaNFRNAMAHPASKEVAHRQQYF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 71.19| 20| 151| 23| 42| 5 --------------------------------------------------------------------------- 23- 42 (36.12/14.76) KKTRKNSL...LAGQSSSPSPYP 178- 200 (35.07/14.13) KNYRNNRLkhiLPRPPPEPTPAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KNYRNNRL 2) KPIYKPQVRYAPSLPQKEYCLPKKTRKNSLLAGQSS 3) PSPYPSRRRRRR | 178 1 38 | 185 36 49 |
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