Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | LKPIYKPQVRYAPSLPQKEYCLPKKTRKNSLLAGQSSSPSPYPSRRRRRRPAGSMDAMEEDTPPAPPLPPPPTTGAKQPPYKDPDDGRQRFLLELEFIQCLANPIYINYLAQNRYFEDEAFIGYLKYLKYWQRPEYIKYIMYPHCLFFLELLQNANFRNAMAHPASKEVAHRQQYFFWKNYRNNRLKHILPRPPPEPTPAPAPAPVPTPPPVPAAPSSLPTMSAVGASAMPPMQFIGTPGTNNPKNDMRNVMGGRKRKMG |
Length | 260 |
Position | Middle |
Organism | Hordeum vulgare subsp. vulgare (Domesticated barley) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Hordeinae> Hordeum. |
Aromaticity | 0.11 |
Grand average of hydropathy | -0.775 |
Instability index | 74.29 |
Isoelectric point | 9.93 |
Molecular weight | 29689.03 |
Publications | PubMed=23075845 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP14812 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.68| 26| 58| 91| 116| 4 --------------------------------------------------------------------------- 91- 116 (47.55/32.48) FLLEL....EFIQCLANPIYINYLAQNRYF 147- 176 (42.13/28.01) FFLELlqnaNFRNAMAHPASKEVAHRQQYF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 71.19| 20| 151| 24| 43| 5 --------------------------------------------------------------------------- 24- 43 (36.12/13.56) KKTRKNSL...LAGQSSSPSPYP 179- 201 (35.07/12.97) KNYRNNRLkhiLPRPPPEPTPAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KNYRN 2) LKPIYKPQVRYAPSLPQKEYCLPKKTRKNSLLAGQ 3) SPYPSRRRRRR | 179 1 40 | 183 35 50 |
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