<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14754

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFSNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHLASTASDGPVPVSPEVEQAMRQWEYNEKLAFHMFQEGLLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPSLLAAHSPHMMIGPNSSGIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNESKNVSAGSPLDLLQVAPSSLPMPGGNTAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRSPAGENVDEHYPKDHEVKLEEQSIMAHMGIDPGTAHIFDEVDKSDFKADFGSEFPIFSPMPGESCENANPSLGRRMSLNGEKLAKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKVLSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQAAGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRSLRREGTAEDVWPASHSSKPCAKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGLKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSHSGMGLFHPSGNGGADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWKEERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTAEWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSAKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPASPISQEPERKSAELSDQGKTATEEEKKSRGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQMMHHPQSTLWGYNLMGQTQQPSFFLQNQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQPPQYPGLQQAQTMPQGYTMYGTQMPLPQPAQPQAGVVLSPSYGSRAYPAAHSSPALMERLRQMQQQPSGYIQQQAPPYLQPLTGAQRMNHQALQQSPLVGGGIDAMMTPAHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREMQQPQQPPQPQPSSQPQSQQTLGLQAVQPQQPLFPRPGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2183
PositionKinase
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.07
Grand average of hydropathy-0.406
Instability index57.42
Isoelectric point7.40
Molecular weight243622.03
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     379.35|      47|      51|    2076|    2122|       1
---------------------------------------------------------------------------
 1861- 1916 (50.78/22.23)	......PSFFLQNQALTPGG...S..RLDPAgsfvptntkqalSNML.QRRSGAMMQP..PS.........LHAITSQQ
 1918- 1962 (41.41/16.50)	L.....IQMKLLQQ..............QQQ............QRLLrQAQARPFQQG..PPgdqaalfaaQARPSPQ.
 1963- 1994 (51.23/22.50)	..............P..PQY...P..GLQQA............QTMP.Q..GYTMYGTQMP..........LPQP.AQP
 1996- 2033 (43.28/17.65)	AgvvlsPSYGSRAYPAAHSS...P..A..................LM.ERL.RQMQQ................QPSGYI
 2034- 2074 (43.71/17.91)	Q.....QQAPPYLQPLTGAQrmnH..QALQQ............SPLV.GGGIDAMMTPAHP..................
 2077- 2122 (86.61/44.10)	......PSVPLPQDPMRPRQ...P..QVRQQ............QRLL.QVWGREMQQPQQPP.........QPQPSSQP
 2130- 2176 (62.33/29.27)	L.....QAVQ.PQQPLFPR....PglQQTQQ............QQQT.AALVRQLQKQLSSN.........QPQQGVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.43|      40|     152|     910|     956|       2
---------------------------------------------------------------------------
  910-  956 (68.51/47.46)	YTTGLCVCivavlrrYHSCLILNPEQTAQVFEGLCGVVKHV..VNPSEC
  966-  996 (47.29/22.77)	YLYDL..........YVSCSHLRS.KFGDLFSSACSKVKQT..I.....
 1072- 1106 (49.62/24.24)	...ELTAC..........CTVLSSEWLG.VLKALCCSSNHVwgFNDVLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.85|      24|      25|    1485|    1508|       3
---------------------------------------------------------------------------
 1485- 1508 (37.12/19.21)	KERDRQKQKSMSLLSQQPFLSLVL
 1512- 1533 (31.20/14.95)	KGQDEQREGLLTSLQNQ..VNQIL
 1538- 1561 (35.53/18.07)	EERYQDDIKARQMMHEALQLRLNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.79|      49|     156|     542|     603|       4
---------------------------------------------------------------------------
  545-  593 (80.85/57.71)	GESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEK
  669-  718 (83.94/36.51)	GTAHIFDEVDKSDFKADFGSEFPIFSPMPGESCENANPSLGRRMSlNGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.27|      20|     152|      79|     104|       5
---------------------------------------------------------------------------
   79-  104 (27.05/28.83)	EKLKLNTFQDtGkkkpqVNAKDNY..WL
  234-  255 (34.22/18.26)	EKLAFHMFQE.G.....LLEKHEYltWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.53|      12|     153|    1623|    1634|       8
---------------------------------------------------------------------------
 1623- 1634 (20.97/13.64)	ASPGGSE.ENKRA
 1778- 1790 (15.56/ 7.82)	ASPISQEpERKSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      13|     286|    1030|    1047|       9
---------------------------------------------------------------------------
 1030- 1042 (20.39/18.38)	MLGKVLSDNAANR
 1050- 1062 (24.07/ 7.43)	LMNVCMGHQDAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.73|      15|     286|    1370|    1389|      15
---------------------------------------------------------------------------
 1370- 1386 (22.56/22.28)	KQCLKDPGSGsvAEMNN
 1393- 1407 (24.17/ 8.09)	KATIEVFQQS..ADLNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.26|      19|     126|    1708|    1730|      16
---------------------------------------------------------------------------
 1708- 1726 (37.37/31.68)	KVSPWD......LFEGQKNPAPLSW
 1737- 1761 (29.90/12.04)	KVIKYEeqhhllLYHTHPTPKPRSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14754 with Med12 domain of Kingdom Metazoa
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