<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14753

Description Mediator complex subunit 25
SequenceMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGLQLRPPQPQPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPTQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length619
PositionUnknown
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.04
Grand average of hydropathy-0.290
Instability index62.42
Isoelectric point9.59
Molecular weight64686.89
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.88|      27|      30|     122|     148|       6
---------------------------------------------------------------------------
  109-  140 (39.56/10.29)	DVSQDPRHmvlvrGLVLPVGG.GSAPGPLQPKQ
  141-  169 (41.05/11.06)	PVPLPPAA...psGATLSAAP.QQSLPPVPPQY
  460-  481 (35.27/ 8.09)	PQPQ.P.Q.....GTV...GAsGATGQP.QPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.51|      23|      26|     251|     273|       8
---------------------------------------------------------------------------
  251-  267 (27.68/ 6.77)	.........PGLAPPAQPGAPSMAGT
  268-  289 (33.13/10.03)	VAPGGV.sgPS...PAQLGAPALGGQ
  297-  322 (28.70/ 7.38)	LAWSGVlewQEKPKPASVDANTKLTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.85|      22|      36|      30|      52|       9
---------------------------------------------------------------------------
   30-   50 (28.90/20.80)	.................EQIGQtHRVC...LLICNSPPYLL
   51-   85 (25.31/12.80)	PAvesttysgytteslvQQIGE.RGIH...FSIVS..PRKL
   86-  101 (17.64/ 6.47)	PA.........................lrlLFEKAAPPALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.46|      18|      23|     355|     372|      10
---------------------------------------------------------------------------
  355-  372 (33.81/20.87)	LTTLGPLFR...NSRMVQFHF
  377-  397 (28.65/16.69)	LESLKGLYRimgNGFAGCVHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.81|      26|     260|     324|     350|      15
---------------------------------------------------------------------------
  324-  350 (43.40/27.65)	LPCQVYVNHGENLKTEQwP........QKLIMQLI
  586-  619 (40.41/19.69)	LPGQMLLSGGPRGPVPQ.PglqpsvmeDDILMDLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14753 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) NHKQVQQQKLEQQRGLQLRPPQPQPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPTQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
129
440
287
617










Molecular Recognition Features






MoRF SequenceStartStop




NANANA