<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14750

Description Cyclin dependent kinase 19
SequenceKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNNTQTNGTTGGTAAGVGGAGAGLQHSQDSGLNQVPPNKKPRLGASGTNSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length415
PositionKinase
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.08
Grand average of hydropathy-0.767
Instability index58.62
Isoelectric point8.47
Molecular weight46878.26
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14750
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.74|      22|      33|     324|     345|       1
---------------------------------------------------------------------------
  300-  319 (34.45/13.99)	QQAAAPPQAPP..QQQNNTQTN
  324-  345 (37.47/15.75)	GTAAGVGGAGAGLQHSQDSGLN
  359-  379 (37.82/15.96)	GTNSGGPVMPSDYQHSS.SRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|      17|     380|     389|       2
---------------------------------------------------------------------------
  380-  389 (18.90/10.35)	YQSSVQGSSQ
  396-  405 (18.45/ 9.96)	YSSSSQQSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      16|      17|     232|     247|       3
---------------------------------------------------------------------------
  232-  247 (27.33/14.29)	DPTKRITSEQALQDPY
  251-  266 (29.32/15.81)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14750 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNNTQTNGTTGGTAAGVGGAGAGLQHSQDSGLNQVPPNKKPRLGASGTNSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
266
415










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLGA
2) QSTLGYSSSSQQSAQYHPSHQAHRY
3) RLNYQSSV
350
391
377
357
415
384