<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14739

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIQNKKSQASVSDPMNALQSLTGGPGTGAAGISMPPRGPGQSLGGMSSLGAMGQSMALSGQPPPGTSGMAPHGMAVVSTAPPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLPQMHHAQHHQPPPQAQQPSVAQNQPSQLTPQSQNQPLVSQAQALPGQMLYPQQQLKFVRAPMVVQQPQVQPQVQPQVQPQVQQQAAVQTAQTTQMVAPGVQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEEDDRQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAS
Length745
PositionTail
OrganismIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Sciuromorpha> Sciuridae> Xerinae> Marmotini> Ictidomys.
Aromaticity0.03
Grand average of hydropathy-0.717
Instability index87.20
Isoelectric point9.33
Molecular weight82244.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14739
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.23|      36|      36|     196|     231|       3
---------------------------------------------------------------------------
  197-  234 (66.94/19.45)	QQFQAVVQQQQQLQQQQ...QQQQHLIKLHHQNQQQIQqqQ
  235-  265 (53.99/13.83)	QQLQRMAQLQLQQQQQQ...QQQQA.L....QAQPPIQ..Q
  315-  349 (43.31/ 9.20)	SQNQPLVSQAQALPGQMlypQQQLKFVRAPMV....VQ..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      16|      19|     381|     399|       4
---------------------------------------------------------------------------
  266-  281 (31.75/ 7.10)	PPMQQPQP..PPSQALPQ
  400-  417 (25.07/ 7.73)	QQVQTPQSmpPPPQPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.83|      20|      21|      86|     106|       5
---------------------------------------------------------------------------
   86-  105 (39.88/24.17)	QSLTGGPGTGAAGISMPPRG
  108-  123 (24.21/ 9.86)	QSLGGMSSLGAMGQSM....
  125-  140 (27.74/ 9.49)	..LSGQPPPGTSG..MAPHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.81|      25|      26|     520|     544|       6
---------------------------------------------------------------------------
  490-  509 (22.62/ 8.52)	LDKLKQL.......SKYIeP..LRRMiNK
  520-  544 (44.14/23.66)	LSKMKSLLDILTDPSKRC.P..LKTL.QK
  549-  572 (36.05/17.97)	LEKLKNDMAVPTPPP....PpvLPTK.QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.95|      15|      43|     418|     436|       7
---------------------------------------------------------------------------
  418-  434 (27.39/10.97)	PGSQPNSnvSSGPAPSP
  441-  455 (26.56/ 6.90)	PSPQPSQ..SPVTARTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     639|     656|       8
---------------------------------------------------------------------------
  639-  656 (32.84/19.09)	VARLDPKFLVNLDPSHCS
  664-  681 (32.24/18.61)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     703|     713|      10
---------------------------------------------------------------------------
  703-  713 (23.12/12.29)	NPFLQSVHR.CM
  731-  742 (18.67/ 8.70)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.57|      14|      22|     577|     590|      13
---------------------------------------------------------------------------
  577-  590 (23.65/13.67)	PLLDAVLA.NIRSPV
  601-  615 (21.91/12.16)	PAMTAIHGpPITAPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14739 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLYPQQQLKFVRAPMVVQQPQVQPQVQPQVQPQVQQQAAVQTAQTTQMVAPGVQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) QNKKSQASVSDPMNALQSLTGGPGTGAAGISMPPRGPGQSLGGMSSLGAMGQSMALSGQPPPGTSGMAPHGMAVVSTAP
3) QQALQAQPPIQQPPMQQPQPPPSQALPQQLPQMHHAQHHQPPPQAQQPSVAQNQPSQLTPQSQNQPLVSQAQALPG
331
70
254
495
148
329










Molecular Recognition Features






MoRF SequenceStartStop




NANANA