<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14728

Description Cyclin dependent kinase 19
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length442
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.08
Grand average of hydropathy-0.657
Instability index56.57
Isoelectric point8.79
Molecular weight49810.80
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14728
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      16|      17|     259|     274|       1
---------------------------------------------------------------------------
  259-  274 (27.33/12.86)	DPTKRITSEQALQDPY
  278-  293 (29.32/14.22)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.19|      28|      37|     364|     400|       2
---------------------------------------------------------------------------
  318-  358 (42.41/12.39)	QHQQPTAPPQqaaAPPQAPPQqqnstqtngtAGGAGAGAGG
  364-  391 (53.78/32.83)	QHSQDSGLNQ...VPPNKKPR..........LGPSGTNSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     127|     166|       3
---------------------------------------------------------------------------
   91-  117 (31.61/20.79)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  120-  159 (59.27/56.92)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  160-  181 (28.35/16.41)	IGCIFAELLTSEPI...FHCRQEDI................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.15|      14|      15|     403|     416|       7
---------------------------------------------------------------------------
  403-  416 (25.83/20.05)	SRLNYQSSVQGSSQ
  419-  432 (25.32/19.48)	STLGYSSSSQQSAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14728 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
293
442










Molecular Recognition Features






MoRF SequenceStartStop




1) QSTLGYSSSSQQSAQYHPSHQAHRY
2) RLNYQSSV
3) VPPNKKPRLGP
418
404
374
442
411
384