<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14720

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGESGGTQNAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNLATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNSESSDKWWHSYHLPSIDDVEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFRMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPTATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWGSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSNLLIPPKYQTPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGSSTNTAASSSASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHPSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2075
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index59.41
Isoelectric point5.69
Molecular weight227594.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14720
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1146.25|     313|    1153|     125|     488|       1
---------------------------------------------------------------------------
  125-  447 (517.51/225.22)	GY..DDDFPVAVEVIVGGVRMVYPSA.FVLISQNDIPVPQSVASTgGHITVGQQ....GLGSVKDPSNC..GMPLTP.PTSPEQAI.IGESGGTQNAVSHLGSQDG.GMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNLATWDFV......DPTQRVSCSCSRHKLLKRCAVG.PSRPPTISQP......GFSAGPsssssLPPPASSKHKTTERQekgDKLQKRP.LIP.FHHRPSVAEE....LCMEQDPPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRN.TSKQMNLNPM..DSPHSPISPLpPTLSPQPRGQETESLDPPSVPVNPAL
  518-  846 (445.60/192.94)	GErcDAKMEVNSESTALQRLLAQPNK.RFKIWQDKQPQMQPLHFL.DPLPLSQQ.pgdSLGEVNDPYTFedGDIKYI.FTANKKC....KQGTEKDSLKKNKSEDGfGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIfdnsddDELGAVSPALRSSKM...PAVGtEDRP..LGKD......GRAAVP.....YPPTVADLQRMFPTP...PSLEQHPaFSPvMNYKDGISSEtvtaLGMMESPMVSMVSTQLTEFRMEVEDGLGSPKPEEIKDFSyVHKVPTFQPFvgSSMFAPLKML.PSQCLLPLKIPDACLFRPSWAIPPKI
  848- 1030 (183.14/60.68)	.................QLPMP.PTAtFIRDGYNNVPSVGSLADP.DYLNTPQMntpvTLNSAAPASNS..GAGVLPsPATPRFSVpTPRTPRTPRTPRGGGTASGqGSVKYDSTDQGSPASTPSTTRPLNSV.EPATMQPIPEAHSLYVTLILSDSVMNIFKDRNF.......DS....CCICACNMNIKGADVG.LYIPDSSNEDqyrctcGFSA............................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.88|      12|      26|    1498|    1509|       2
---------------------------------------------------------------------------
 1478- 1489 (18.91/ 6.41)	GQNPSTGASSSE
 1498- 1509 (22.59/ 9.34)	GGDTEPGQSSSQ
 1525- 1536 (20.38/ 7.58)	GIPTEPDSADSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.69|      35|     363|    1570|    1659|       3
---------------------------------------------------------------------------
  450-  488 (57.27/14.91)	NGLELQ......QLSTLDDRTVLVGQRLPLMAevseTALYCGI.RP
 1585- 1626 (56.42/83.69)	NSFILQivpcqyMLQTMKDEQVFYIQYLKSMA....FSVYCQCrRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.29|      46|     467|    1302|    1354|       4
---------------------------------------------------------------------------
 1302- 1354 (68.20/59.37)	FRDLSAVYEMCRLgqhKPICKVLRDgIMRV.GKTVAQK...LTDELVSewfSQPWGS
 1774- 1823 (72.09/41.03)	LKDWSILLGECSL...QTISKRLKD.VCRMcGISAADSpsiLSACLVA...MEPQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    1933|    1960|       6
---------------------------------------------------------------------------
 1933- 1960 (37.05/33.00)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 1963- 1991 (44.88/28.76)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.08|      16|     469|    1196|    1211|       7
---------------------------------------------------------------------------
 1196- 1211 (31.05/17.24)	PFLQDAIQKKRT..GRTW
 1664- 1681 (25.02/12.52)	PFILAPIKDKQTelGETF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.15|      17|      18|    1097|    1114|       8
---------------------------------------------------------------------------
 1097- 1114 (27.72/19.65)	HTQPFASLSFlDYI.SSNN
 1116- 1133 (29.43/16.24)	QTLPCVSWSY.DRVqADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.35|      15|      29|    1714|    1728|      10
---------------------------------------------------------------------------
 1714- 1728 (27.56/17.90)	ELLETC..IVNI.ALPNR
 1743- 1760 (24.78/15.29)	KLWEWCigIVQMtSLPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      18|      22|    1865|    1882|      13
---------------------------------------------------------------------------
 1865- 1882 (32.43/22.15)	PTSSTIQVA...PANYPNEDG
 1885- 1905 (29.46/19.24)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14720 with Med13 domain of Kingdom Metazoa
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