<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14718

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKSNSQADTVDFSIIAVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKNKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKTSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKNPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDSMDGQVGVSTNSSSHPMSSKHSMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDRDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1503
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
Lineage
Aromaticity0.05
Grand average of hydropathy-0.693
Instability index53.79
Isoelectric point8.78
Molecular weight159734.05
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14718
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     387.36|      64|      64|    1025|    1088|       2
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  523-  585 (48.08/ 9.37)	.SQ....NPI...LT..SLLQITGNGGSTIG.S...SPTP..PHHTPPP.....................vSSMAGNTKnhpMLM.NLLKDNPAQDF....ST.....LY
 1008- 1054 (68.05/16.87)	TSS....GSV...SS..SGSK.SHHS.................HS.......................SS.SSASNSGK...MKS.SKSEGSSSSKL...SSS.....IY
 1055- 1114 (85.90/23.58)	SSQ....GSS...GS..SQSKTSSQSGGKPG.S...SPIT..KHGLSSG.........................SSSTK...M....KPQGKPSSLM...NPSlskpnIS
 1115- 1171 (43.62/ 7.70)	PSHsrppGGS...DK..LASPMKPVPGTPPS.SkakSPI.......SSG...............sggSHM.SGTSSSTG...MKS.S.......SGL.............
 1241- 1303 (53.02/11.23)	..P....GSE...DSmdGQVGVSTNSSSHPM.S...S.....KHSMSGG................efQGK.REKSDKDK...SKV.STSGGSVDSSK...KTS.....ES
 1304- 1386 (44.31/ 7.96)	KNV....GST...GV..AKIIISKHDGGSPSiK...AKVTlqKPGESSGeglrpqmassknygspliSGS.TPKHERGS...PSH.SKSPAYTPQNL...DSE.......
 1387- 1474 (44.38/ 7.98)	SES....GSSiaeKS..YQNSPSSDDGIRPL.P...EYST..EKHKKHK.kekkkvkdkdrdrdrdrDRD.KKKSHSIK...PESwSKSPISSDQSLsmtSNT.....IL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     261.91|      50|      50|     248|     297|       3
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  196-  246 (34.38/15.29)	....PLiM........GSHPVdnkWTPSF.SSITSansvdlpacFFL.KFPQPIPVSRA.................F...VQKL...Q..
  248-  297 (95.00/57.28)	CTGIPL.F........ETQPT...YVPLY.ELITQ.........FELSKDPDPVPLNHNM...............RF...YAALPGQQHC
  307-  348 (35.08/15.77)	...................PD...GRSLQgTLVSK.........ITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  358-  413 (52.34/27.72)	SPGLLQ.F........EV.......CPLS.E..SR.........FSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
  425-  471 (45.11/22.72)	CMSIPV.TmrairrkaETIQA...DTPAL.SLIA...........ETVED....MVKKNL...............P....PASSPG....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      17|      22|     801|     820|       4
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  801-  820 (29.12/19.79)	GFGEeyfDESSQSGDNDDFK
  899-  915 (25.42/ 9.37)	GNGT...SNSSLSGPGLDSK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     266.70|      61|     499|     678|     738|       5
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  592-  658 (32.39/ 8.48)	..........RQ.......NSSSGsprmemcsgsnktkkkkssrlppdKPKHQTEDDFQRELFSMDVDS....QNPifDV.NMTAD.............tlD
  659-  723 (96.41/39.64)	TPHI.TPA..PS.......QCSTP...................pttypQPVPHPQPSIQRMVRLSSSDS....IGP..DVTDILSDIAEEASKLPSTSD..D
  724-  800 (78.07/30.72)	CPPIGTPV..RD.......SSSSG......hsqsalfdpdvfqtnnneNPYTDPADLIADAAGSPSSDSptnhFFP..DGVDFNPDL......LNSQSQ..S
  827-  886 (59.83/21.84)	LNTLGVPMlgGDngeskfkSNSQA........................DTVDF...SIIAV....AGKA....LGP....ADLMEHHSGSQSPLLTTGD...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.82|      46|     499|     476|     521|       6
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  476-  521 (82.68/36.60)	TGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSK
  961- 1006 (81.14/35.77)	TGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.76|      20|      22|    1173|    1193|       9
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 1173- 1193 (31.64/18.96)	SSGSlSQKNPPSSNSCTASSS
 1197- 1216 (32.12/14.73)	SSGS.SMSSSQNQHGSSKGKS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14718 with Med1 domain of Kingdom Metazoa
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