<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14716

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISENKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGPTVGPLPHDVEVAIWQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDHNSSVIFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGSGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRPWDVIWDLGARGGGEGAAAATQAPPEVHKIERGSICVLSHQQGRAAGLKLGLKIPILPPFPEGSGRRELGVVCWVLQVWFSLQLSEWGEQQTQSSCPVFLPLSPSLHH
Length2153
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.452
Instability index54.77
Isoelectric point6.67
Molecular weight239327.14
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14716
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.05|      16|      16|    2003|    2018|       1
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 2003- 2018 (34.83/17.66)	QQQQQQQQQQQ....QQQQQ
 2020- 2039 (29.23/13.65)	QQQQQQQQQQQyhirQQQQQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     415.67|     103|     103|    1789|    1891|       2
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 1691- 1794 (113.51/55.75)	YLEPLPLPPEDE..EPPAPTLLEPEKKAPEPPKtdkPGAAP...PST...EERKKKSTkgK.KRSQPA...............TKTEdyGMgSGRSGpygvtvppdlLHHPNPGSISHLSyrQG......SIGL
 1795- 1905 (179.70/93.16)	YTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPY...PGVLPTTMTGVMGLEPSYKTSV..Y.RQQQPAVPQG....QRLRQQLQQSQ..GM.LGQSS..........VHQMTPSSSYGLQtsQGytpyvsHVGL
 1906- 1991 (122.46/60.81)	..QQHTGPA.GTMVPP....SYSSQ..PYQSTH...PSTNPTLVDPTRHLQ.Q.RPSG..YvHQQAPTYGHGltstQRFSHQTLQQT..SM.IG...............TMTPLGAQSVQ..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     656.10|     181|     187|    1188|    1374|       3
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 1026- 1166 (162.06/87.17)	...................................DIAILCAELTGYCKSL.....SAEWLG..VLKALCCS.....SNngtcgfndllcnvDVSDLSFHDSLATFVAILIA......................RQCL..LLEDLIRCAAIPSLLNAACSEQDS...ePGARLTC..riLLHLFKTPQLNPCQ.......SDGNKPTVGIRSSCDRHLLaASQN
 1188- 1374 (289.04/179.29)	LKGSGFTVTGgtEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCED.....SN.............DLQDPVLSSAQAQRLMQLICYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMRQSSLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVL.SSLE
 1392- 1567 (205.00/113.58)	VQGHVLKAAG..EEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQvrqivNN.............WRDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAV....LLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGSMEENKRAYM...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.75|      15|     187|     623|     637|       4
---------------------------------------------------------------------------
  623-  637 (31.99/18.04)	GDLAF..GAPGP..RPPSP
  803-  821 (20.76/ 8.66)	GDLTFlgGEDGQkrRRNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.58|      28|     179|     372|     404|       7
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  374-  403 (44.10/43.47)	CPSALVWhYSLT.....DSRIKTGSPLdHLPIAPS
 2118- 2150 (49.48/23.89)	CWVLQVW.FSLQlsewgEQQTQSSCPV.FLPLSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     664|     122|     135|       9
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  122-  135 (24.94/15.63)	GTKPLTQLAKKVPI
  787-  800 (25.11/15.80)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.23|      17|     338|     251|     267|      12
---------------------------------------------------------------------------
  251-  267 (33.52/21.74)	DRHEFLTWVLECFEKIR
  590-  606 (30.71/19.30)	ERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.11|      65|     610|      27|      99|      18
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   27-   99 (89.47/90.70)	QDPKQKEDELTAlNVKQgfnNQPAVSGD...EHGSakNVNFNPAKiSSNFsSIIAEKLRCNTLPDTGRRKPQVNQK
  643-  710 (109.64/77.00)	DDPERKEAEGSS.SSKL...EDPGLSESmdiDHNS..SVIFEDME.KPDF.SLFSPTMPCEGKGSPSPEKPDVEKE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14716 with Med12 domain of Kingdom Metazoa
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