<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14710

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length458
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.08
Grand average of hydropathy-0.798
Instability index54.08
Isoelectric point8.55
Molecular weight51785.72
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14710
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.18|      95|     151|      12|     118|       1
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   12-  118 (144.38/114.23)	ERERVE.DLFEYeGCKVGR.GTYGHVYKARRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVFlshsdRKVwllfDYAEHDLWHIIKFHRASKANK
  165-  263 (158.80/95.23)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifSVMGFPADKDWEDIR..KMPEYPTLQKDF.....RRT....TYANSSLIKYMEKHKVKPDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.12|      15|      17|     416|     432|       2
---------------------------------------------------------------------------
  416-  432 (23.21/21.52)	HsgSRLNYQSSVQGSSQ
  434-  448 (26.91/17.09)	Q..STLGYSSSSQQSAQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.70|      18|      23|     328|     346|       3
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  328-  345 (36.15/19.51)	Q..QQQQNQHQ.QPTAPPQQA
  350-  370 (24.54/ 7.41)	QapPQQQNSTQtNGTAGGAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      17|     275|     290|       4
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  275-  290 (28.65/18.40)	DPTKRITSEQALQDPY
  294-  309 (30.88/20.37)	DPLPTLDVFAGCQIPY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14710 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
309
458










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHPSHQAHRY
2) NKKPRLG
3) QSTLGYSSSS
4) RLNYQSSV
447
393
434
420
458
399
443
427