<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14706

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMQQQFQVAVQQQQQQLQQQQQQQQHLIKLHHQNQQQMQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAATLPGQMLYAQPQLKLVRAPMVVQQPQVQPQVQPQVQPQTAVPTAQASQIVGSGVQVSQSSLTMLSSPSPSQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCARKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length549
PositionTail
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.03
Grand average of hydropathy-0.734
Instability index93.45
Isoelectric point9.21
Molecular weight61013.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.12|      26|      35|      49|      83|       2
---------------------------------------------------------------------------
   49-   78 (52.32/10.27)	L..QLQQQQQQQQQQalqaQPPMQQPPMQQPQ
   85-  112 (43.80/ 8.46)	LpqQLQQLHHPQHHQ....PPPQPQPPVAQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.57|      19|      19|       7|      25|       4
---------------------------------------------------------------------------
    3-   22 (30.78/ 9.69)	QQFqVA...VQQQQQQLQQQQQQ
   23-   42 (31.26/ 9.99)	QQHlIK...LHHQNQQQMQQQQQ
  143-  164 (26.52/ 7.00)	LKL.VRapmVVQQPQVQPQVQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.18|      18|      34|     183|     200|       5
---------------------------------------------------------------------------
  183-  200 (31.82/14.32)	GVQV..................SQSSLTMLSSPSPS
  202-  237 (22.36/ 7.89)	QVQTpqsmppppqpspqpgppsSQPNSNVSSGPTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      35|     294|     324|       7
---------------------------------------------------------------------------
  294-  324 (40.72/34.35)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  331-  360 (46.90/29.78)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.73|      36|     112|     363|     401|      11
---------------------------------------------------------------------------
  363-  398 (70.72/29.63)	PTPPPPPV......PPTK......Q.QYLCQPLLDAVLANIRSPVF....NHS
  477-  529 (45.01/11.70)	PSVPPLELsvpadyPAQSplwidrQwQYDANPFLQSVHRCMTSRLLqlpdKHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14706 with Med15 domain of Kingdom Metazoa
Unable to open file!