<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14702

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length502
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.09
Grand average of hydropathy-0.708
Instability index52.20
Isoelectric point8.66
Molecular weight56742.49
Publications









Function






Annotated function


GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14702
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.21|      16|      17|     319|     334|       1
---------------------------------------------------------------------------
  319-  334 (27.33/18.43)	D.PTKRITSEQALQDPY
  338-  353 (29.32/20.37)	D.PLPTLDVFAGCQIPY
  362-  376 (14.56/ 6.07)	DePEEKGDKNQQQQQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.36|      17|      24|     377|     399|       2
---------------------------------------------------------------------------
  378-  397 (29.74/18.52)	QHQQPTAPPQqaaAPPQAPP
  424-  440 (29.62/ 9.70)	QHSQDSGLNQ...VPPNKKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.50|      23|      25|      17|      41|       3
---------------------------------------------------------------------------
   17-   41 (33.05/30.47)	EDLFEYEGCKVgRGTyGHVYKARRK
   44-   66 (40.46/25.56)	KDEKEYALKQI.EGT.GISMSACRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.35|      15|      37|     151|     165|       4
---------------------------------------------------------------------------
  151-  165 (25.86/19.36)	DLKPANILVMGEGPE
  173-  183 (14.46/ 7.30)	DMGFARLF...NSP.
  189-  203 (27.03/20.60)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.93|      20|      21|     453|     472|       5
---------------------------------------------------------------------------
  453-  467 (23.57/11.01)	.....VMP.SDYQHSGSRLNY
  468-  483 (22.29/10.05)	QSSVQ...gS..SQSQSTLGY
  488-  500 (19.08/ 7.64)	QQSAQYHP.SHQAH.......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14702 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPQQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLGPSGTNSGGPVMPSDYQHSGSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
353
502










Molecular Recognition Features






MoRF SequenceStartStop




1) PNKKPRLG
2) QSTLGYSSSSQ
3) RLNYQSSV
4) SAQYHPSHQAHRY
436
478
464
490
443
488
471
502