<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14700

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISENKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGPTVGPLPHDVEVAIWQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDHNSSVIFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGSGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRPWDVIWDLGARGGGEGAAAATQAPPEVHKIERGSICVLSHQQGRAAGLKLGLKIPILPPFPEGSGRRELGVVCWVLQVWFSLQLSEWGEQQTQSSCPVFLPLSPSLHH
Length2179
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.423
Instability index53.98
Isoelectric point6.59
Molecular weight242434.93
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14700
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.84|      20|      20|    2029|    2048|       1
---------------------------------------------------------------------------
 1899- 1914 (20.90/ 6.43)	....RQQQPAVPQGQRLRQQ
 2029- 2048 (39.61/18.73)	QQQQQQQQQQQQQQQQQQQQ
 2050- 2066 (28.33/11.31)	QQQQQQQYHIRQQQQQQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     192.61|      35|      44|    1930|    1965|       2
---------------------------------------------------------------------------
 1822- 1853 (40.91/18.44)	LHHPNPGSISHLSYRQGS......IGLytQNQP..LPAGG
 1856- 1883 (43.15/19.88)	VDPYRP.VRLPMQKLPTRPPY...PGV..L......PTTM
 1930- 1965 (61.81/35.55)	VHQMTPSSSYGLQTSQGYTPYvSHVGL..QQHT..GPADP
 1977- 2010 (46.73/22.19)	VHQQAPTYGHGLTSTQRF....SHQTL..QQTSmiGTMTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     323.16|      86|     126|    1473|    1564|       3
---------------------------------------------------------------------------
 1270- 1323 (72.48/29.96)	SVETAS....LDVYAKYVLRSICQQEWVGERCLKSLCED.....SNDLQDPVLSSAQAQRLMQ.......................................
 1473- 1563 (132.37/77.03)	SMSLLS....QQPFLSLVLTCLKGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHeaLKLRLNLVGGmFDTV......QRST.QQTTEWAvlLL
 1601- 1692 (118.32/49.92)	SISQGSmeenKRAYMNLV...KKLQKELGERQSDSL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKIAG.FDSIfkkeglQVSTkQKISPWD..LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.81|      37|      44|     942|     978|       6
---------------------------------------------------------------------------
  942-  978 (65.64/38.95)	QDQMAQVFEGLCGVVKHGM..NRSDGSSAERCILAYLYD
  987- 1025 (59.17/34.40)	KSKFGELFSDFCSKVKNTIycNVEPSESNMRWAPEFMID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.90|      55|     342|     209|     267|      13
---------------------------------------------------------------------------
  209-  267 (97.73/69.07)	GPAGSGGCGPTVGPLPHDVevaIWQWdYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIR
  552-  606 (94.17/55.70)	GSIASGSLSAPSAPIFQDV...LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.81|      68|     200|    1191|    1267|      15
---------------------------------------------------------------------------
 1191- 1267 (93.49/86.35)	SDGNKPTVGIRSSCDRHLLaASQNRivdGAVFAVLKAVFVLgDAELKGSGFTVTGgtEELpeEEGGG.GSGGRRQGGR
 1400- 1468 (111.33/70.20)	SSGNTASNMPSSSKTKPVL.SSLER...SGVWLVAPLIAKL.PTSVQGHVLKAAG..EEL..EKGQHlGSSSRKERDR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14700 with Med12 domain of Kingdom Metazoa
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