<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14693

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMNVTNARHRDSAGAEEAMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGPAPPSTAATAAPGSDKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKTGEFPSTSRISG
Length251
PositionHead
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.05
Grand average of hydropathy-0.980
Instability index59.10
Isoelectric point9.72
Molecular weight27034.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14693
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.34|      17|      17|     207|     223|       1
---------------------------------------------------------------------------
  187-  201 (26.01/11.04)	P..PKKKNKHKHKQSRT
  207-  223 (29.10/13.08)	PETPSDSDHKKKKKKKE
  226-  242 (28.23/12.51)	PERKRKKKEKKKKKTGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.18|      12|      16|      60|      72|       2
---------------------------------------------------------------------------
   33-   44 (25.25/ 6.71)	PPPTALGFGPGK
   61-   72 (23.94/ 9.74)	PPSTAATAAPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.30|      23|      47|     106|     128|       5
---------------------------------------------------------------------------
  105-  127 (40.68/23.77)	NLEHS......YNKFCGKKVKEKLSNF......L.P
  128-  152 (18.30/ 7.29)	DLPGMidlpgsHDNSSLRSLIEK...........pP
  153-  177 (27.31/13.92)	ILGGS......FNPITG....TMLAGFrlhtgpL.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14693 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGS
2) MNVTNARHRDSAGAEEAMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGPAPPSTAATAAPGS
3) TMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKTGEFPSTSRISG
125
1
164
157
72
251










Molecular Recognition Features






MoRF SequenceStartStop




1) AMENFTALFGA
2) SDSDHKKKKKKKEEDPERKRKKKEKKKKKTGEFPSTSRIS
17
211
27
250