<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14690
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MAPHSMAVVSTAAPQTQLQLQQAALQQQQQQFQQQVALQQQQQQLQAQQSAMQQQFQVAVQQQQQQLQQQQQQQQHLIKLHHQNQQQMQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQLHHPQHHQPPPQPQPPVAQNQPSQLPPQSQTQPLVSQAATLPGQMLYAQPQLKLVRAPMVVQQPQVQPQVQPQVQPQTAVPTAQASQIVGSGVQVSQSSLTMLSSPSPSQQVQTPQSMPPPPQPSPQPGPPSSQPNSNVSSGPTPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCARKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA |
Length | 600 |
Position | Tail |
Organism | Sus scrofa (Pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.732 |
Instability index | 95.30 |
Isoelectric point | 9.21 |
Molecular weight | 66668.01 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14690
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 252.56| 33| 33| 21| 53| 1
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13- 45 (46.73/ 6.97) .APQTQLQ....lQ.QAALQQQQQQFQQQVALQQQQQQL
46- 77 (45.85/ 6.65) QAQQSAMQ....qQfQVAVQQQQQQLQQQ...QQQQQHL
108- 143 (52.39/ 9.08) QQQQQALQaqppmQ.QPPMQQPQPPPSQ..ALPQQLQQL
147- 176 (56.88/10.74) QHHQPPPQ.....P.QPPVAQNQ...PSQLPPQSQTQPL
262- 293 (50.71/ 8.45) PPPQPSPQ.....P.GPPSSQPNSNVSS.GPTPSPSSFL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 69.85| 19| 28| 375| 401| 5
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375- 393 (33.52/26.40) LSKMKSLLDILTDPSKRCP
404- 422 (36.33/12.67) LEKLKNDMAVPTPPPPPVP
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