<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14687

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLESEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGESGGTQNAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNLATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNSESSDKWWHSYHLPSIDDVEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFRMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPTATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWGSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSNLLIPPKYQTPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGSSTNTAASSSASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHPSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2181
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index58.58
Isoelectric point5.56
Molecular weight239361.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14687
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      27|      28|     980|    1006|       1
---------------------------------------------------------------------------
  980- 1006 (48.71/22.85)	PDYLNTPQMNTPVTLNSAAPASNSGAG
 1011- 1034 (44.66/20.32)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1050- 1068 (26.51/ 8.99)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     727.40|     212|     363|    1548|    1765|       2
---------------------------------------------------------------------------
  416-  594 (247.86/114.02)	SQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEEL.CMEQDPPGQKLGLAGIDSSlEVSSSRkydKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTL.SP.QPRGQ............ETESL..DppSVPVNpalYGNGLELQ......QLSTLDDRTVLVGQRLPLMAevseTALYCGI.RP.................................
 1549- 1764 (351.29/179.90)	SASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIgCGGDTEPGQSSSQPSQDGQ.ESVTER...ERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAeED.STSGNFWLLSLM...RCYTEML..D..NLPEH...MRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMA....FSVYCQCrRPLPTQIHIKSLTGFGPAASIeMTLKNPER.PSPI
 2017- 2128 (128.25/55.77)	.................................................................................................NLHP..SPNS..SPVP....SPgSPSG.IGVGSHFqhsRSQGERLlsR..EAPEE...LKQ....QPLALGYFVSTAKAENL..PQWFWSSC....PQAQNQC..PLFLKASLHHHISVAQTDEL.LPARNSQRvPHPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.97|      40|      71|     809|     849|       3
---------------------------------------------------------------------------
  809-  834 (30.12/14.82)	..............................................TEDRPLGKDGRAAvPYPPTVADLQRM
  835-  905 (54.05/26.14)	FPTPPSLEQHPAFSPvmnykdgissetvtalgmmespmvsmvstqlTEFRMEVEDGLGS.PKPEEIKDFSYV
  908-  955 (46.79/21.52)	VPTFQPFVGSSMFAP..................lkmlpsqcllplkIPDACLFRPSWA...IPPKIEQL...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.98|      56|    1264|     131|     187|       4
---------------------------------------------------------------------------
  131-  187 (99.72/79.73)	ESEH.LSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVS.....PYG
 1396- 1459 (86.26/63.42)	ENEAlLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSewfsqPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      20|      24|    1942|    1961|       5
---------------------------------------------------------------------------
 1942- 1961 (32.55/15.77)	VFGRSTALNMQSSQLNTPQD
 1967- 1986 (31.53/15.04)	ILVFPTSSTIQVAPANYPNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.91|      19|      24|      65|      84|       6
---------------------------------------------------------------------------
   65-   83 (36.10/22.37)	QANLLCV............WRRDVKPDCKEL
   91-  121 (25.81/ 8.67)	EPNLVGVihhelqvveeglWENGLSYECRTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.56|      27|      28|    1095|    1121|      11
---------------------------------------------------------------------------
 1095- 1121 (53.00/33.23)	DRNFDSCCICACNMNIK.GADVGLYIPD
 1125- 1152 (46.56/28.27)	EDQYRCTCGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.21|      28|    1498|     637|     666|      13
---------------------------------------------------------------------------
  637-  666 (47.94/31.32)	STALQRLLAQPNKrfKIWQDKQPQMQ......PLHF
 2134- 2167 (46.27/24.08)	SDVLRFVLEQYNA..LSWLTCNPATQdrtsclPVHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      26|    1310|    1327|      15
---------------------------------------------------------------------------
 1310- 1327 (33.04/19.06)	KKRTGRTWENIQHVQGPL
 1333- 1350 (32.51/18.62)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.94|      14|      26|    1355|    1368|      16
---------------------------------------------------------------------------
 1355- 1368 (24.90/14.92)	LLVGY....DKDFLTISP
 1378- 1395 (21.05/11.44)	LLDPYgghrDVAYIVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.71|      19|     394|     322|     340|      18
---------------------------------------------------------------------------
  322-  340 (36.36/20.08)	SQDG.GMITMHSPKRSGKIP
  718-  737 (31.35/16.20)	SEDGfGTKDVTTPGHSTPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.29|      17|      17|    1204|    1220|      21
---------------------------------------------------------------------------
 1204- 1220 (30.27/17.33)	TQPFASLSFLDYISSNN
 1223- 1239 (33.02/19.62)	TLPCVSWSYDRVQADNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14687 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
2) ECILNRTQSKRSQMSTPTLEEEPANNLATWD
3) GILMTGNLHPSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVP
5) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGESGGTQNAVSHLGSQDGGMITMHSPKRSGKIPPKLH
6) PPKYQTPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGSSTNTAASSSASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
405
354
2011
707
276
1496
974
555
384
2059
823
344
1639
1071










Molecular Recognition Features






MoRF SequenceStartStop




1) RFKIW
650
654