<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14685

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKSNSQADTVDFSIIAVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKNKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKTSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKNPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDSMDGQVGVSTNSSSHPMSSKHSMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDRDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
Lineage
Aromaticity0.04
Grand average of hydropathy-0.684
Instability index54.21
Isoelectric point8.88
Molecular weight168335.99
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14685
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     425.62|      64|      64|    1101|    1164|       2
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  599-  661 (48.08/10.32)	.SQ....NPI...LT..SLLQITGNGGSTIG.S...SPTP..PHHTPPP.......................vSSMAGNTKnhpMLM.NLLKDNPAQDF....ST.....LY
  787-  842 (38.26/ 6.34)	.......AEE...AS..KLPSTSDDC..PPI.G...TPV...RDSSSSG.....................hsqSALFDPDV...FQT.NNNENPYTD.....PAD.....LI
 1084- 1130 (68.05/18.41)	TSS....GSV...SS..SGSK.SHHS.................HS.......................SS...SSASNSGK...MKS.SKSEGSSSSKL...SSS.....IY
 1131- 1190 (85.90/25.65)	SSQ....GSS...GS..SQSKTSSQSGGKPG.S...SPIT..KHGLSSG...........................SSSTK...M....KPQGKPSSLM...NPSlskpnIS
 1191- 1247 (43.62/ 8.51)	PSHsrppGGS...DK..LASPMKPVPGTPPS.SkakSPI.......SSG...............sggSHM...SGTSSSTG...MKS.S.......SGL.............
 1317- 1379 (53.02/12.32)	..P....GSE...DSmdGQVGVSTNSSSHPM.S...S.....KHSMSGG................efQGK...REKSDKDK...SKV.STSGGSVDSSK...KTS.....ES
 1380- 1462 (44.31/ 8.79)	KNV....GST...GV..AKIIISKHDGGSPSiK...AKVTlqKPGESSGeglrpqmassknygspliSGS...TPKHERGS...PSH.SKSPAYTPQNL...DSE.......
 1463- 1550 (44.38/ 8.82)	SES....GSSiaeKS..YQNSPSSDDGIRPL.P...EYST..EKHKKHK.kekkkvkdkdrdrdrdrDRD...KKKSHSIK...PESwSKSPISSDQSLsmtSNT.....IL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     261.91|      50|      50|     324|     373|       3
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  272-  322 (34.38/16.29)	....PLiM........GSHPVdnkWTPSF.SSITSansvdlpacFFL.KFPQPIPVSRA.................F...VQKL...Q..
  324-  373 (95.00/60.31)	CTGIPL.F........ETQPT...YVPLY.ELITQ.........FELSKDPDPVPLNHNM...............RF...YAALPGQQHC
  383-  424 (35.08/16.80)	...................PD...GRSLQgTLVSK.........ITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  434-  489 (52.34/29.33)	SPGLLQ.F........EV.......CPLS.E..SR.........FSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
  501-  547 (45.11/24.08)	CMSIPV.TmrairrkaETIQA...DTPAL.SLIA...........ETVED....MVKKNL...............P....PASSPG....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.50|      19|      22|     877|     896|       4
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  879-  898 (31.30/21.65)	GEEYFDESSQSgDNDDFK.......GF
  916-  941 (20.21/ 6.83)	GESKFKSNSQA.DTVDFSiiavagkAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.62|      46|     499|     552|     597|       5
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  552-  597 (84.64/33.26)	TGNNPMSGTTTPTNTFP...GGPITTLFNM.SMSIKDRHESVGHGEDFSK
  743-  778 (37.72/10.55)	......SQCSTPPTTYPqpvPHPQPSIQRMvRLSSSD...SI..GPD...
 1037- 1082 (76.26/29.20)	TGGSKSPGSSGRSQTPP...GVATPPIPKI.TIQIPKGTVMVGKPSSHSQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.40|      23|      23|     954|     976|       6
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  692-  708 (28.13/11.40)	SSRLP......PDKPKHQTEDDF
  954-  976 (35.91/16.98)	QSPLLTTGDLGKEKTQKRVKEGN
  980-  994 (23.23/ 7.89)	NSSLSGPG.LD.......SKPGK
  995- 1014 (28.13/11.40)	RSRTPSNDGKNKDKPPKRKK...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      48|     146|     183|       7
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  146-  164 (21.42/ 7.51)	..................................NFD.EFSKHLKGLVNLYNLP
  165-  213 (53.46/29.65)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  216-  269 (48.91/26.51)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.76|      20|      23|    1249|    1269|       8
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 1249- 1269 (31.64/15.54)	SSGSlSQKNPPSSNSCTASSS
 1273- 1292 (32.12/12.08)	SSGS.SMSSSQNQHGSSKGKS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14685 with Med1 domain of Kingdom Metazoa
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