<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14685

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKSNSQADTVDFSIIAVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKNKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKTSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKNPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDSMDGQVGVSTNSSSHPMSSKHSMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDRDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
Lineage
Aromaticity0.04
Grand average of hydropathy-0.684
Instability index54.21
Isoelectric point8.88
Molecular weight168335.99
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14685
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     425.62|      64|      64|    1101|    1164|       2
---------------------------------------------------------------------------
  599-  661 (48.08/10.32)	.SQ....NPI...LT..SLLQITGNGGSTIG.S...SPTP..PHHTPPP.......................vSSMAGNTKnhpMLM.NLLKDNPAQDF....ST.....LY
  787-  842 (38.26/ 6.34)	.......AEE...AS..KLPSTSDDC..PPI.G...TPV...RDSSSSG.....................hsqSALFDPDV...FQT.NNNENPYTD.....PAD.....LI
 1084- 1130 (68.05/18.41)	TSS....GSV...SS..SGSK.SHHS.................HS.......................SS...SSASNSGK...MKS.SKSEGSSSSKL...SSS.....IY
 1131- 1190 (85.90/25.65)	SSQ....GSS...GS..SQSKTSSQSGGKPG.S...SPIT..KHGLSSG...........................SSSTK...M....KPQGKPSSLM...NPSlskpnIS
 1191- 1247 (43.62/ 8.51)	PSHsrppGGS...DK..LASPMKPVPGTPPS.SkakSPI.......SSG...............sggSHM...SGTSSSTG...MKS.S.......SGL.............
 1317- 1379 (53.02/12.32)	..P....GSE...DSmdGQVGVSTNSSSHPM.S...S.....KHSMSGG................efQGK...REKSDKDK...SKV.STSGGSVDSSK...KTS.....ES
 1380- 1462 (44.31/ 8.79)	KNV....GST...GV..AKIIISKHDGGSPSiK...AKVTlqKPGESSGeglrpqmassknygspliSGS...TPKHERGS...PSH.SKSPAYTPQNL...DSE.......
 1463- 1550 (44.38/ 8.82)	SES....GSSiaeKS..YQNSPSSDDGIRPL.P...EYST..EKHKKHK.kekkkvkdkdrdrdrdrDRD...KKKSHSIK...PESwSKSPISSDQSLsmtSNT.....IL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     261.91|      50|      50|     324|     373|       3
---------------------------------------------------------------------------
  272-  322 (34.38/16.29)	....PLiM........GSHPVdnkWTPSF.SSITSansvdlpacFFL.KFPQPIPVSRA.................F...VQKL...Q..
  324-  373 (95.00/60.31)	CTGIPL.F........ETQPT...YVPLY.ELITQ.........FELSKDPDPVPLNHNM...............RF...YAALPGQQHC
  383-  424 (35.08/16.80)	...................PD...GRSLQgTLVSK.........ITF.QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  434-  489 (52.34/29.33)	SPGLLQ.F........EV.......CPLS.E..SR.........FSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
  501-  547 (45.11/24.08)	CMSIPV.TmrairrkaETIQA...DTPAL.SLIA...........ETVED....MVKKNL...............P....PASSPG....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.50|      19|      22|     877|     896|       4
---------------------------------------------------------------------------
  879-  898 (31.30/21.65)	GEEYFDESSQSgDNDDFK.......GF
  916-  941 (20.21/ 6.83)	GESKFKSNSQA.DTVDFSiiavagkAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.62|      46|     499|     552|     597|       5
---------------------------------------------------------------------------
  552-  597 (84.64/33.26)	TGNNPMSGTTTPTNTFP...GGPITTLFNM.SMSIKDRHESVGHGEDFSK
  743-  778 (37.72/10.55)	......SQCSTPPTTYPqpvPHPQPSIQRMvRLSSSD...SI..GPD...
 1037- 1082 (76.26/29.20)	TGGSKSPGSSGRSQTPP...GVATPPIPKI.TIQIPKGTVMVGKPSSHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.40|      23|      23|     954|     976|       6
---------------------------------------------------------------------------
  692-  708 (28.13/11.40)	SSRLP......PDKPKHQTEDDF
  954-  976 (35.91/16.98)	QSPLLTTGDLGKEKTQKRVKEGN
  980-  994 (23.23/ 7.89)	NSSLSGPG.LD.......SKPGK
  995- 1014 (28.13/11.40)	RSRTPSNDGKNKDKPPKRKK...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      48|     146|     183|       7
---------------------------------------------------------------------------
  146-  164 (21.42/ 7.51)	..................................NFD.EFSKHLKGLVNLYNLP
  165-  213 (53.46/29.65)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  216-  269 (48.91/26.51)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.76|      20|      23|    1249|    1269|       8
---------------------------------------------------------------------------
 1249- 1269 (31.64/15.54)	SSGSlSQKNPPSSNSCTASSS
 1273- 1292 (32.12/12.08)	SSGS.SMSSSQNQHGSSKGKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14685 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKNKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKTSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKNPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDSMDGQVGVSTNSSSHPMSSKHSMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDRDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFN
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKSNSQAD
937
538
575
869
1579
571
866
927










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFDE
2) IKAKVTLQK
3) IRPLPEYSTEKHKKHKKEKKKVKDK
4) KITIQIPK
5) KPSLTAVIDKLKHG
6) RLSPDFMIGEEDDDLMDV
7) VAKIIISKH
878
1402
1484
1062
1298
1557
1387
885
1410
1508
1069
1311
1574
1395