<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14684

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNTKDNYWLVPARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQTTDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPGLLAAHSPHVMIGPNNASIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADENYPKDHDVKMEIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTEPGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARTINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNSNVNSLKNDDFTMRGLRRDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSADASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRMDRKVVKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSGIYRVPPNYSPISSQMMHHPQSALWGYNLMGQPQQPGFFLQNQSLPPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQPPPSGYAQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRSRQPQVRQQQRLLQVWGWE
Length2070
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index55.37
Isoelectric point7.60
Molecular weight231424.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14684
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.26|      13|      19|    1779|    1791|       1
---------------------------------------------------------------------------
 1779- 1791 (24.33/14.66)	SSRVDEYPQSGIY
 1801- 1813 (26.92/17.12)	SSQMMHHPQSALW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     664.89|     178|     251|    1576|    1758|       2
---------------------------------------------------------------------------
 1435- 1572 (131.39/63.35)	................GE...ELEKGQHLGSSSKKERDRQKQKS.MSLLSQQPFLS...L......VL....TC.............LKGQD..EQREGLLTSLQNQVnqilSNWreeryqddikarqmmhEALQL..RLN...LVGGMFDTVQ..RSTQWTTDWALLLL...QiitsGTVDMHTNNE.....LFTTVLDM...........................
 1576- 1758 (289.97/161.53)	LINGTLASDLSNASPGGS...EENKRAYMNLVKKLKKELGDKRS.ESIDKVRQLLP...LPKQTCDVI....TCEPMGSliDTKGNKIAGFDsiDKKQGLQVSTKQKV....SPW................DLFEG..QKNPAPLSWAWFGTVRMDRKVVKYEEQHHLLL...Y....HTHPMPKPRS.....YYLEPLPLPPEEEEEEPTSPISQePERKSAELSDQ
 1828- 2017 (243.52/124.38)	LQNQSLPPGGSRLDPTGSfvpTNTKQALSNMLQRRSGAMMQPPSlHAITSQQQLIQmklLQQQQQQRLlrqaQTRPFQQ..GQPGDQAALF...........AAQARP....SPQ...............lPQYPGlqQAQTMPQGYTMYGT.QMPLQQTPQQQAGSVVLsptY....NSRTYPAAHSnpalmERLRQMQPPPSGYAQQQASPYLQ.PLTGSQRLNHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.84|      42|     153|     490|     536|       3
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  490-  536 (60.63/57.23)	ANQNKDnqEVAPNDEAV.VTLLCEWAV.SCKRS....GkhRAMAV..AKLLeKRQ
  639-  688 (59.22/37.91)	AGENAD..ENYPKDHDVkMEIFSPMPGeSCENAnpslG..RRMSVngEKLL.KRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     215.17|      45|     152|     875|     921|       4
---------------------------------------------------------------------------
  875-  919 (81.44/39.30)	YTTGL..CVCIVAV..LRRYHSCL..ILNPEQTAQVFEGL...CGVVKHVVNPS
 1034- 1063 (42.81/16.02)	FSSEL..TAC............CT..VLSSEWLG.VLKAL...CCSSNHV....
 1065- 1110 (43.28/18.72)	...GFndVLCTVDVsdLS.FHDSLatFIAILIARQCF.SL...EDVVQHVALPS
 1126- 1162 (47.63/20.06)	RMT....CRLLLHL..FRAPQACL..L..PQATGKPFPGIrssCD..RH.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.30|      12|     203|      21|      33|       9
---------------------------------------------------------------------------
   21-   33 (20.65/12.94)	PPDVyPQDPKQKE
  220-  231 (25.65/11.55)	PPDV.EQAMRQWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.15|      30|     254|     554|     584|      11
---------------------------------------------------------------------------
  554-  584 (46.39/35.82)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPSL
  811-  841 (49.76/33.66)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      15|      19|    1364|    1382|      15
---------------------------------------------------------------------------
 1367- 1382 (22.70/24.85)	SADLNNNSSNsGMGLF
 1389- 1403 (25.97/11.29)	SADASSTRQN.GIKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      31|     732|     743|      17
---------------------------------------------------------------------------
  732-  743 (22.36/16.97)	GVGKERDEARHQ
  764-  775 (21.93/16.47)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.56|      27|      31|    1246|    1272|      18
---------------------------------------------------------------------------
 1246- 1272 (49.24/32.34)	VLRTICQQEWVGEHCLKEPERLCTDKE
 1278- 1304 (47.31/30.76)	VLSNMQAQKLLQLICYPHGIKECTEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.30|      20|      31|     921|     943|      19
---------------------------------------------------------------------------
  921-  943 (30.65/28.63)	CSSPERCIlaYlYDLYVSCSHLR
  954-  973 (35.66/21.48)	CSKVKQTI..Y.NNVIPANSNLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14684 with Med12 domain of Kingdom Metazoa
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