<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14681

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETNFEGDDGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDSIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPAAKRKREGEGRVFREKWERDYFFVEVKSMPTCLICKKIVSVLKEYNLKRHYESRHSKSYDQYTEQTRDAILNELKRALSVSRAHHEEGPGW
Length806
PositionUnknown
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.06
Grand average of hydropathy-0.345
Instability index58.77
Isoelectric point9.08
Molecular weight85812.31
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.17|      24|      27|     318|     344|       3
---------------------------------------------------------------------------
  320-  344 (44.04/11.07)	FSQATPPTLPPGPPGApKAPPASQ...P
  635-  661 (31.13/ 7.78)	LRPQNPGANPQLRSLL.LNPPPPQtgvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.03|      44|      74|     429|     487|       4
---------------------------------------------------------------------------
  429-  487 (56.46/70.87)	PCQVYVNHgeNLKTEQwpQKLIMQLIP..........QQLLTtlgplfrNSRMVQfhftNKDLESLKGL
  506-  559 (71.57/42.88)	PCEVRVLM..LLYSSK..KKIFMGLIPydqsgfvngiRQVIT.......NHKQVQ....QQKLEQQRGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.76|      19|      20|     352|     370|       6
---------------------------------------------------------------------------
  352-  370 (33.64/ 6.98)	PGPGLAPAAAQPGAPSMAG
  374-  392 (33.11/ 6.77)	PGGVSGPSPAQLGAPALGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.19|      43|      66|      86|     130|       9
---------------------------------------------------------------------------
   86-  130 (70.44/55.41)	APTSSAYEFVTWLDSIKFMGGGGESCSLIAEGLSTALQLFddFKK
  155-  197 (71.75/49.41)	AVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLL..FEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.39|      12|     390|     299|     319|      10
---------------------------------------------------------------------------
  290-  306 (11.90/ 7.17)	EAAknqkAGLGPRfSPI
  703-  714 (22.49/11.36)	SWP....AQLPPR.APM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.18|      21|     377|     198|     221|      12
---------------------------------------------------------------------------
  198-  221 (35.79/20.31)	AAPPAMLEPLQPPadvSQDPRHMV
  576-  596 (39.39/16.25)	ARPSQNLLQLRPP...QPQPQGAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14681 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPAAKRKREGEG
232
545
391
725










Molecular Recognition Features






MoRF SequenceStartStop




NANANA