<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14678

Description Mediator of RNA polymerase II transcription subunit 13
SequenceAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLGGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLRKKEESKEEEELGYDDDFPIAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVTSAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVTGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTHSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTLSQPGFSAGPSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTSGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSALDDRTVLVGQRLPLMAEVSETALYCGIRSSNAESSDKWWHSFRLPPSDDAEFRPPELQGERCDAKMEVNTESTALQRLLAQPNKRFKIWQDKQSQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTHLTEFKMEVEDGLGSPKPEEIKDFSYVHRVPTFQPFMGSSMFAPMKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQNTFLPQMEGARKTQETPMSLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHAWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPVCKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPATAQGHTMPGNTGPLASNSGSAAPQAGSAFNPTTSNGSSANPAASTSTSGSSVPPVSSSASAPGINQMSTTSSSGFSGSVGGQNPGTGASSTDRTQGNISCGGDTEPGQGSSQPSQDGQESVTDRERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDCTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQVVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNSNFDSTLSVRSRKSKVSPRKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAEHLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2195
PositionMiddle
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.07
Grand average of hydropathy-0.405
Instability index57.70
Isoelectric point5.69
Molecular weight241502.47
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14678
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.19|      27|      28|    1589|    1615|       1
---------------------------------------------------------------------------
  285-  317 (33.32/13.02)	.QQGLGSVKDPSN.C.GMPLTPPT.......SPeqavtgesGG
 1006- 1039 (34.83/13.99)	SNSGAGVLPSPAT.P.RFSVPTPR.......TPrtprtprgGG
 1040- 1072 (25.34/ 7.87)	TASGQGSVKYDSTdQGSPASTPSTtrplnsvEP..........
 1591- 1619 (42.70/19.06)	QNPGTGASSTDRT.QGNISCGGDT.......EP......gqGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.98|      28|      28|    1522|    1549|       2
---------------------------------------------------------------------------
  418-  440 (32.14/10.81)	....PTLSQPGFSAGPSSSSLPPPASS.
  515-  535 (33.02/11.33)	MNLNPMDSPHSP.....ISPLPPTLS..
 1522- 1545 (34.62/12.26)	....PLASNSGSAAPQAGSAFNPTTSNG
 1546- 1568 (38.20/14.36)	SSANPAASTSTS.....GSSVPPVSSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1102|    1126|       3
---------------------------------------------------------------------------
 1102- 1126 (51.64/31.70)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1129- 1157 (36.91/20.54)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.62|      14|      32|     336|     350|       4
---------------------------------------------------------------------------
  336-  350 (22.76/17.44)	HSpKRSGKIPPKLHN
  366-  379 (25.86/14.02)	HS.KRSQMSTPTLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      33|      37|      29|      62|       5
---------------------------------------------------------------------------
   29-   62 (56.10/42.19)	DDPILLSFIRC.LQANLLCVWRRDVKPDCKELwIF
   66-   99 (54.09/34.46)	DEPNLGGVIHHeLQVVEEGLWENGLSYECRTL.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     249.84|      79|     635|    1425|    1515|       6
---------------------------------------------------------------------------
 1425- 1515 (113.99/77.22)	LGQHKPvcKVLRDGIMRVGKTVAQKLTDELvSEWFsqpWSS.EENDNHSRLKLYAQVcRHHLapylaTLQLDSSLLIPPKYQTPPATAQGHT
 2067- 2146 (135.85/62.80)	LSREAP..EELKQQPLALGYFVSTAKAEHL.PQWF...WSScPQAQNQCPLFLKASL.HHHI.....SVAQTDELLPARNSQRVPHPLDSKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.35|      33|      36|     832|     864|       7
---------------------------------------------------------------------------
  832-  855 (35.78/14.19)	..................TVADLQRM..FPTPPSLEQHPAFSPV
  856-  881 (35.29/13.89)	MNYKDGISS........eTVTALGMM..........ESPMVSMV
  890-  927 (36.73/14.77)	MEVEDGLGS.....pkpeEIKDFSYVhrVPTFQPFMGSSMFAP.
  928-  965 (39.55/16.50)	MKM...LPShcllplkipDACLFRPS..WAIPPKIEQLP.MPPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.15|      16|      36|     540|     558|       8
---------------------------------------------------------------------------
  540-  558 (24.47/23.94)	GQETESLDPPSvpvNPALY
  578-  593 (27.68/16.67)	GQRLPLMAEVS...ETALY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.22|      11|      31|     682|     696|      11
---------------------------------------------------------------------------
  682-  696 (14.61/20.26)	DSLGEVNDpytfEDG
  715-  725 (19.61/10.61)	DSLKKNKS....EDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14678 with Med13 domain of Kingdom Metazoa
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