<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14675

Description Mediator complex subunit 23
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLSAFKQFWSGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLTAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWILGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNESDIITHFSIQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERYLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNVMNPREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLHYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMSSGSPVPQSNPVPAPLPGAQ
Length1371
PositionTail
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.10
Grand average of hydropathy-0.017
Instability index45.65
Isoelectric point7.19
Molecular weight156764.49
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14675
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     510.87|     184|     524|     147|     431|       1
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  191-  402 (302.38/347.25)	RKLYPEgKLPHWILGNLVSDFVDTFRPTARI..NSICGRcsLLPVVNNsgAICNSWKLDP.....ATLRFPLKGLLPY.DKD...LFEPQTALLRYVLEQPY.SRDMVCNMLGLNKQHKQRCPVLED.........................................................................................................................................................qlvdlvvyamerseteekfddgGTSQLLWQHLSSQLIFFV..LFQFASFPHMV...LSLHQKLAGRGLIK.G...RDHLMWVlLQFISGSIQKNALADFLPVMK.LF
  928- 1049 (142.76/59.81)	HKKYPE.KLYFEGLAEQVDPPVQIQSPYLPIyfGNVCLR..FLPVFDI..VIHRFLELLPvskslETLLDHLGGLYKFhDRPvtyLYNTLHYYERYLRNRDHlKRKLVHAIIGSLKDNRPQGWCLSD....................................................................................................................................................................................................................................................................
 1225- 1308 (65.74/ 6.07)	...............................................................................................................................tylknvmnprednpwvpddsyyckligrlvdtmagkspgpfpncdwrfnefpnpaahalhvtcvelmalavsgkdvgnallnvvlksqplvprenitawmnaigliitalpepywivlhdrivsvissssltsetewvgypfrlfdftachqsysemscsytlalahavwhhssiGQLSLIPKFLTEVLIPIVktEFQLLYVYHLVgpfLQRFQQERTRCMIEiGvafYDMLLNV.DQCSTHLHYMDPICDFLYHMKyMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.44|      77|      80|     449|     528|       2
---------------------------------------------------------------------------
  449-  528 (130.25/88.60)	PIPHSLKLHHEF.LQQSLRNKSLQMNDYK..IALLCNAYSTNSEcftLPMGALVETIYGNGIMRIPLPGT.SCLASGSI.TPLPM
  529-  610 (107.19/64.73)	NLLDSLTVHAKMsLIHSIATRVIKLAHAKssVALAPALVETYSR...LLVYMEIESLGIKGFISQLLPTVfKSHAWGILhTLLEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.19|      51|     711|      32|      92|       3
---------------------------------------------------------------------------
   32-   92 (84.12/71.81)	TPEDEKTKLISC....LSA.FKQ....................FWSGLSQESHeqciqwIVKFIHGQHSPKrisfLYDCL..AMAVET
  726-  803 (72.06/41.17)	TPHNWASHTLSCfpgpLQAfFKQnnvpqesrfnlkknveeeyrKWKSMTNESD......IITHFSIQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.11|      15|     711|     653|     667|       5
---------------------------------------------------------------------------
  653-  667 (26.26/20.65)	LRLITALGSSE...VQPQ
 1332- 1349 (23.84/17.91)	LRFITHISKMEpaaVPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.30|      35|     302|     850|     887|       6
---------------------------------------------------------------------------
  850-  887 (58.13/41.24)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCY.F
 1156- 1191 (58.17/33.43)	ITALPEPYW...IVLHDRIVSVISSSSLTSETEWVGYpF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14675 with Med23 domain of Kingdom Metazoa
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