<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14673

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMRVSNDGCFMTYIVESEKLNKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTASPIILHENNVPRSLGMNASVTVEGTSAMYKLPIAPLIMGSHPADNKWTPSFSAITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFESQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGVSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMDMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNTQVDTVDFSIISVAGKALGAAELIEHHSGSQSPLLTTGDLGKEKTPKRVKEGNGTSSSSLSGPGSDSKPGKRSRTPSNDGKSKDRPPKRKKGDTEGRSPSHSSNRPFTPPTSTGGSRSPGSAGRSQTPPGVTTPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASTSGKMKSSKSEGSSSSKLTSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGASDKLASPMKPVPGTPPTSKAKSPISSGSGGSHMSGTSSGSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSFPSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTGGPGGEDAMDGQMGVSANSASHLMSSKHNMSGGEFQGKREKSEKDKSKVSTSGGSGDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1584
PositionMiddle
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.05
Grand average of hydropathy-0.652
Instability index54.14
Isoelectric point8.91
Molecular weight168642.55
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14673
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     501.97|      50|      51|     998|    1047|       1
---------------------------------------------------------------------------
  656-  698 (37.59/ 8.18)	KDNPA..Q.....DFSTLY..................GS......SPLERQN......S.SSG.SP.R............mdmcSGS...NK....T.....KK..K..KS
  699-  752 (34.06/ 6.54)	SRLPP..D....KPKHQTE..................DDfqrelfSMDVDSQNPIFDVN.MTA.DTlDT...............P.....HI....T.....PA..PSQCS
  971- 1011 (57.02/17.19)	KEKTP..K....RVK...E..................GN......GTSSSS...LSGP....G.SD.SK...............PGK..RSR....T.....PS..NDGKS
 1012- 1061 (80.71/28.17)	KDRPP..K....RKKGDTE..................GR......SPSHSSNRPFTPPT.STG.GS.RS...............PGSagRSQ....T.....PP....GVT
 1062- 1114 (41.32/ 9.91)	TPPIP..KitiqIPKGTVM..................VG......KPSSHSQ.....YT.SSG.SV.SS...............SGS..KSHhshsS.....SS..SSSSS
 1115- 1177 (44.45/11.36)	ASTSG..K....MKSSKSE..................GS......SSSKLTSSVYSSQG.SSG.SS.QS......knssqsggkPGS..SPI....T.khglSS..GSGST
 1178- 1218 (47.46/12.76)	KMKP..............Q..................GK.......PSSLMN.PLSKPNiSPS.HS.RP...............PGA..SDK....L.....AS..PMKPV
 1219- 1284 (35.75/ 7.32)	PGTPPtsK....AKSPISS..................GS......GGSHMS......GT.SSGsGM.KSssglgssgslsqktpPSS..NSC....TasssfPS..S.GSS
 1373- 1439 (36.62/ 7.73)	SGGSG..D....SSKKTSEsknvgstgvakiiiskhdGG......SPSIKAKVTLQKP....G.ES.SG...............EGL..RPQ....M.....ASskNYGSP
 1442- 1491 (45.71/11.94)	SGSTP..K....HERG.............................SPSHSKSPAYTPQN.LDS.ES.ES..........gssiaEKS..YQN....S.....PS..SDDGI
 1513- 1556 (41.30/ 9.90)	KDRDR..D....RDK.DRD...................K......KKSH.SIK....PE.S...WS.KS...............PIS..SDQ....S..lsmTS..NTILS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.73|      13|      26|     333|     345|       2
---------------------------------------------------------------------------
  305-  319 (17.07/ 6.42)	LPacFFLKFPQPIPV
  333-  345 (23.98/12.20)	IP..LFESQPTYVPL
  361-  373 (20.67/ 9.43)	IP..LNHNMRFYAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.47|      38|      50|     152|     189|       3
---------------------------------------------------------------------------
  152-  189 (64.88/32.86)	NFD.EFSKHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQD
  202-  240 (56.76/27.90)	NAG.PLDKILHGSVG.YLT..........PrsGGHLMNLKYYASPSDLLDD
  256-  299 (34.82/14.48)	SLGmNASVTVEGTSAMYKLpiaplimgshP..ADNKW.TPSFSAITS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.35|      12|      50|     906|     922|       4
---------------------------------------------------------------------------
  640-  651 (24.01/ 6.05)	SMAGNTKNHPML
  906-  917 (22.34/17.26)	SQALNTLGVPML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.39|      18|      22|     883|     903|       5
---------------------------------------------------------------------------
  883-  901 (31.01/23.93)	G.FGEEYFDESSQSgDNDDF
  919-  937 (27.37/ 9.42)	GdNGETKFKGNTQV.DTVDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.56|      15|      31|    1252|    1266|       6
---------------------------------------------------------------------------
 1252- 1266 (23.84/ 7.64)	SSGLGSSGSLSQKTP
 1286- 1300 (23.46/ 7.40)	SSSQNQHGSSKGKSP
 1321- 1335 (23.26/ 7.26)	TGGPGGEDAMDGQMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.93|      26|      55|     402|     430|       8
---------------------------------------------------------------------------
  402-  430 (39.67/38.86)	ITFQHPGRVPLIlnMIRHQVAYNTLIgSC
  458-  483 (48.26/33.47)	VSFQHPVNDSLV..CVVMDVQDSTHV.SC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.61|      17|      56|     558|     577|       9
---------------------------------------------------------------------------
  539-  555 (30.68/11.18)	EDMVKKNLPPASSPGYG
  561-  577 (33.92/22.52)	NPMSGTTTPTNTFPGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.79|      46|      98|       4|      52|      12
---------------------------------------------------------------------------
    4-   52 (72.06/56.16)	SNDGCFMT...YIVESEkLNKMSSLLERLHAKFNQNRPWSEtiKLVRQVMEK
  103-  151 (77.73/49.91)	SGTECYITsdmFYVEVQ.LDPAGQLCDVKVAHHGENPVSCP..ELVQQLREK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14673 with Med1 domain of Kingdom Metazoa
Unable to open file!