<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14669
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLEASLDALLSQAADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGSGQPGQPGAGTILAGTSGLQQVQMAGTPSQQQPMLSGVQMAPAGQPGKMPSGIKTNIKSASMHPYQR |
Length | 268 |
Position | Head |
Organism | Cavia porcellus (Guinea pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae>
Cavia.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.584 |
Instability index | 47.74 |
Isoelectric point | 6.45 |
Molecular weight | 29154.60 |
Publications | PubMed=21993624
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14669
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.97| 23| 27| 165| 191| 1
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165- 191 (35.23/23.19) GLRPNKQTFNPADTNALvaavAFGKGL
198- 220 (40.74/19.42) GSSGSGQPGQPGAGTIL....AGTSGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.19| 24| 27| 59| 84| 2
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59- 84 (32.97/35.50) LNKvLKHEKTPLFRNQViIP..LVLSPD
89- 114 (38.22/29.14) LMR.QTEGRVPVFSHEV.VPdhLRTKPD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.48| 15| 19| 229| 243| 3
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229- 243 (27.83/19.03) PSQQQPMLSGVQMAP
251- 265 (26.65/17.92) PSGIKTNIKSASMHP
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|