<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14667

Description Mediator complex subunit 23
SequenceYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNESDIITHFSIQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERYLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNVMNPREDNPWVPDDSYYCKLIGRLSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLHYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMSSGSPVPQSNPVPAPLPGAQ
Length1004
PositionTail
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.10
Grand average of hydropathy-0.052
Instability index48.14
Isoelectric point7.50
Molecular weight114974.88
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14667
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.05|      76|      80|      90|     168|       4
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   90-  168 (128.28/114.02)	IPHSLKLHHEF.LQQSLRNKSLQMNDYK..IALLCNAYSTNSEcftLPMGALVETIYGNGIMRIPLPGT.SCLASGSI.TPLPM
  170-  250 (105.77/83.42)	LLDSLTVHAKMsLIHSIATRVIKLAHAKssVALAPALVETYSR...LLVYMEIESLGIKGFISQLLPTVfKSHAWGILhTLLEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.86|      38|     330|     351|     398|       5
---------------------------------------------------------------------------
  351-  398 (67.96/56.89)	QGtWC.KD.ILQTIMSFTPHN.WAS.HTLSC......FPGPLqaffkqnnvPQ.ESRFN
  683-  731 (55.89/29.27)	QG.WClSDtYLKNVMNPREDNpWVPdDSYYCkligrlSPGPF.........PNcDWRFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.34|      28|     358|     575|     607|       7
---------------------------------------------------------------------------
  575-  607 (46.52/39.62)	LY.....FEG..LAEQVDPPVQIQSPYLPIYfgnvcLRFL
  934-  968 (38.81/21.37)	LYhmkymFTGdsVKEQVEKIICNLKPALKLR.....LRFI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14667 with Med23 domain of Kingdom Metazoa
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