<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14661
Description |
Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MASAGVVPGRQAEDALPPPSESPLPETKPLPTPQPPPPVAAPPPQQSPAPRPQSPAGVKEEENYSFLPLVHNIIKCMDKDSPDVHQDLNALKTKFQEMRRLISTMPGIQLSPEQQQQQLHNLREQVRTKNELLQKYKSLCMFEIPKE |
Length | 147 |
Position | Middle |
Organism | Cavia porcellus (Guinea pig) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae>
Cavia.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.793 |
Instability index | 104.08 |
Isoelectric point | 6.31 |
Molecular weight | 16411.65 |
Publications | PubMed=21993624
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP14661
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.41| 14| 16| 23| 36| 1
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17- 34 (25.07/ 6.14) PP.psesPLPETKPLPTPQ
35- 53 (26.34/ 6.76) PPppvaaPPPQQSPAPRPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.94| 18| 29| 85| 102| 2
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85- 102 (29.27/20.29) HQDLNALKTKFQEMRRLI
116- 133 (28.67/19.76) QQQLHNLREQVRTKNELL
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|