<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14659

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLNKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTASPIILHENNVPRSLGMNASVTVEGTSAMYKLPIAPLIMGSHPADNKWTPSFSAITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFESQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGVSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGVEEKRQNNQAWDTSLLSHCIHSTVSKNGKDVRSTSAYLLLLVSYLFLGFLIKICSDVHEDFRFEFRVS
Length615
PositionMiddle
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.07
Grand average of hydropathy-0.168
Instability index48.96
Isoelectric point7.86
Molecular weight68566.36
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.11|      38|      48|     146|     183|       2
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  146-  183 (65.20/46.59)	NFD.....EFSKHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQD
  196-  234 (56.48/39.30)	NAG.....PLDKILHGSVG.YLT..........PrsGGHLMNLKYYASPSDLLDD
  246-  293 (34.43/20.88)	NVPrslgmNASVTVEGTSAMYKLpiaplimgshP..ADNKW.TPSFSAITS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.13|      14|      32|     526|     539|       3
---------------------------------------------------------------------------
  526-  539 (22.48/15.42)	SLIAETVEDMVKKN
  561-  574 (24.65/17.58)	SLLSHCIHSTVSKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.78|      46|      53|     364|     415|       4
---------------------------------------------------------------------------
  299-  362 (49.24/31.91)	...LPA...CF...FLKFPQPIPVSRAfvqkLQNCtgiplfesqptyvpLYEL..ITqFelsKDPDPIPLNHNM....R
  364-  415 (74.99/71.18)	YAALPGQqhCY...FLNKDAPLPDGRS....LQGI..............LVSK..IT.F...QHPGRVPLILNMirhqV
  417-  457 (43.56/25.99)	YNTLIGS..CVkrtILKEDSPGLLQFE....VCPL..............SESRfsVS.F...QHP..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.12|      18|      35|     505|     522|       5
---------------------------------------------------------------------------
  505-  522 (30.17/23.58)	PVTMRAIRRKAETIQA.DT
  542-  560 (26.95/20.27)	PASSPGVEEKRQNNQAwDT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14659 with Med1 domain of Kingdom Metazoa
Unable to open file!