<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14658

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETNFEGDDGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDSIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAHNAAPALSPLQAGAVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGVSHTLPRSLTCPSPCADGGTAGTPRSGPHSGGPSEALAESGEDDGLVRDRAGQPQRGLRPPQPQPQGTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGKGAPAASRWLGKSAIAKGSP
Length708
PositionUnknown
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.06
Grand average of hydropathy-0.255
Instability index57.93
Isoelectric point8.78
Molecular weight74331.13
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14658
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     842.78|     270|     331|       3|     333|       2
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   13-  333 (424.43/166.76)	GLVADVVfviegtanLGPYFEGLRKHYLLPAIEYFNGG...P.....PAETNFEGDDGGTQYS....LVVFNTVDCAPESyvqcHAPTS.SAYEFVTWLDSIKFMGGGGEscSLIAEGLSTALqlfddfkkMREQIGQThrvcLLICNSPPYLLPAVESTTYSGYTTESL.....VQEIGERG.IHFSIVSPRKLPALRLLFEKAAPPAM.LEP........................LQPPADVSqdprHmVLVRGLVLP..VGGGSTPG.PLQ.PKQQVPLPPVPPSGPTL......SAAPQQSLPpvPPQYQVPGnlsaaqvaaqNAVEAAKNQKAGL.................GPRFSPinPLqqaasgVGPPFSQATPPTLPPGPP
  345-  685 (418.35/110.48)	NLVSTVV........PGPGLAPAAAHNAAPALSPLQAGavaPggvsgPSPAQLGAPALGGQQSvsnkLLAWSGVLEWQEK....PKPASvDANTKLTRSLPCQVYVNHGE..NLKTEQWPQKL........IMQLIPQQ....LLTTLGPLFRNSRMVQFHFTNKDLESLkglyrIMGNGFAGcVHFPHTAPCEVRVLMLLYSSKKKIFMgLIPydqsgfvngirqvitnhkqvqqqkLEQQRGVS....H.TLPRSLTCPspCADGGTAGtPRSgPHSGGPSEALAESGEDDglvrdrAGQPQRGLR..PPQPQPQG..........TGVPPPQASLHHLqppgapallppphqslgQPQLGP..PL......LHPPPAQSWPAQLPPRAP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14658 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAHNAAPALSPLQAGAVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGVSHTLPRSLTCPSPCADGGTAGTPRSGPHSGGPSEALAESGEDDGLVRDRAGQPQRGLRPPQPQPQGTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGKGAPAASRWLGKSAIAKGSP
232
549
395
708










Molecular Recognition Features






MoRF SequenceStartStop




1) MPGKGAPAASRWLGKSAIAKGSP
686
708