<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14655

Description Mediator complex subunit 25
SequenceMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQSGLQPSVMEEDILMDLI
Length620
PositionUnknown
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.04
Grand average of hydropathy-0.265
Instability index62.98
Isoelectric point9.53
Molecular weight64739.99
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14655
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.59|      28|      30|     455|     482|       2
---------------------------------------------------------------------------
  455-  482 (57.95/12.08)	GLQLRPPQPQ.PQGAVGASGAAG...QPQAPG
  483-  514 (40.64/ 6.25)	TTQAPPGAPQgPPGAAPGPPPPGpilRPQNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.25|      19|      27|     527|     553|       3
---------------------------------------------------------------------------
  527-  551 (28.99/12.43)	PPPQTgVP...PPQASLhhlqpPGAPAL
  572-  593 (31.27/ 6.05)	PPAQS.WPaqlPPRAPM.....PGQMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.42|      26|      27|     249|     274|       5
---------------------------------------------------------------------------
  151-  192 (26.72/ 7.10)	GPTLSAAPQQslppvppqyqvPGNLSAAQVAAQNAVeaaknQ
  250-  277 (45.70/18.36)	GPGLAPAAAQ...........PGAPSMAGAVAPGGV...sgP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.36|      14|      60|     291|     304|       7
---------------------------------------------------------------------------
  291-  304 (23.93/12.78)	QSVSNKLLAWSGVL
  349-  362 (22.43/11.55)	QLIPQQLLTTLGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.04|      22|     319|      71|      92|       8
---------------------------------------------------------------------------
   71-   92 (37.37/18.87)	GERG.IHFSIVSPRKLPALRLLF
  367-  385 (27.19/12.08)	..RM.VQFHFTN.KDLESLKGLY
  391-  413 (36.49/18.28)	GFAGcVHFPHTAPCEVRVLMLLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14655 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSTPGPLQPKQQVPLPPVPPSGPTLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQATPPTLPPGPPGAPKAPPASQPNLVSTVVPGPGLAPAAAQPGAPSMAGAVAPGGVSGPSPAQLGAPALG
2) NHKQVQQQKLEQQRGLQLRPPQPQPQGAVGASGAAGQPQAPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQSGLQPSVMEEDILMD
129
441
288
618










Molecular Recognition Features






MoRF SequenceStartStop




NANANA