<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14654

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNADKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQILGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRSFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSINDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGKLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFLSVSAADREDGPVMALLLQQLKENIQDMIFRKPGKHARTGTKRKLSDDSCPVESKKTKRSGEACAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHHLQEMFNKTPNVDQLLLVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHNTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSSILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1453
PositionTail
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.06
Grand average of hydropathy-0.184
Instability index52.11
Isoelectric point8.94
Molecular weight160530.56
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14654
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1163.45|     355|     392|     621|    1011|       1
---------------------------------------------------------------------------
  458-  613 (110.65/48.27)	..............................................................................................................................................................................................................................................................LH..SGMF..........QLM.LYGLD.QA....T..LDDMEKsinddmkriIPWIQQLKFWLGQQRCKQSIKHLPTiSSETLQLSNYSTHPIGKLSKNKLFIKLtRLPQYYIV..VEMLE..VPnK......PT.....QLSYKYYFL.........SVSAADREDG.PVMALLLQQLKENI.QdmifrkPGKHARTGTKR
  621- 1011 (552.55/394.16)	PVESKKTkrsgeacAFNKVLAHFVAMCDTNMPfVGLRLELS...NLEIPHQGVQV.EGDGFSHAIrllKIPPckGVNEET.QKALDRSLLDCTFRLQGRNNrTWV.AELVFANCP...LNGTStrEQGPSRHVylTYENLLSEPVGGRKVVEMFLN..........DWnsIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYrkliLCYGTTK..GSSI...SIQwNSIHQKfhiSLGTVGpnsgcSNCHNTILHHLQEMFNK...TPNVDQLL.LVLFDTQA....P..LNAINK.........LPTVPMLGLTQRTNTAYQCFSILPQ.SSTHIRLAFRNMYCIDIYCRSRGVVAI.RDGAYSLFDNSKLVEGFYP.A......PG.....LKTFLNMFVdsnQDARRRSVNEDDNPPS.PIGGDMMDSLISQL.Q......PPPQQQPFPKQ
 1019- 1403 (500.26/282.70)	PLTSPPT.......SYHNTVNQSPSMMHTQSP.GNLHAASSpsgALRAPSPASFVpTPPPSSHGI...SIGP..GASFASpHGTLDPSSPYTMVSPSGRAG.NWPgSPQVSGPSPatrLPGMS..PANPSLHS..PVPDASHSPRAGTSSQTMPTNmppprklpqrSW..AASIPTILTHSALNILLLPSPTPGLVPGLAGSY....LCSPLERflGSVImrrHLQ.RIIQQE...TLQLIN.....SNEPGVIMFKTDALKCRvalSPKTNQTLqLKVTPENAgqwkPdeLQVLEK.........FFETRVAGPPFKANTLI.AFTKLLG.APTHI...LRD..CVHIM....KLELF.PDQATQLKWNVQFCLTIPP.SappiapPGtpavvLKSKMLFFL...QLTQKTSV.....PPQePV..SIIVPIIYDMaS......GTTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     246|     275|       2
---------------------------------------------------------------------------
  246-  275 (48.89/38.76)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/35.71)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.07|      32|      32|      66|      97|       3
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   66-   97 (51.31/39.05)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
   99-  130 (52.75/40.38)	LLALVKWANNADKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      32|     359|     370|       4
---------------------------------------------------------------------------
  359-  370 (20.47/14.91)	IKIDENDVSKPL
  390-  401 (20.28/14.69)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      31|     135|     145|       5
---------------------------------------------------------------------------
  135-  145 (16.90/11.38)	RLASLARDALV
  168-  178 (20.20/15.45)	RLPTCIRDKII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14654 with Med14 domain of Kingdom Metazoa
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