<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14649

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQNQHQQPTAPAPQAAAPPQAPPPQQSSTQTNGTTGGVAAGMGATAAGLQHSQDSGLSQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLTYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length501
PositionKinase
OrganismCavia porcellus (Guinea pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Caviidae> Cavia.
Aromaticity0.09
Grand average of hydropathy-0.654
Instability index55.42
Isoelectric point8.66
Molecular weight56622.52
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14649
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.69|      16|      17|     319|     334|       1
---------------------------------------------------------------------------
  319-  334 (27.35/18.04)	DPTKRITSEQALQDPY
  338-  353 (29.34/19.93)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.49|      36|      37|     423|     459|       2
---------------------------------------------------------------------------
  377-  421 (35.44/13.32)	QHQQPTAPApqaaappQAPPPQQSS..TqtnGTTgGVA.AGMGATAAG..
  423-  458 (64.66/32.77)	QHSQDSGLS.......QVPPNKKPR..L...GPS.GAS.SGGPVMPSDYQ
  468-  498 (28.39/13.47)	........S.......SVQGSSQSQstL...GYS.SSSqQSAQYHPSHQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      37|     151|     165|       3
---------------------------------------------------------------------------
  151-  165 (26.77/16.22)	DLKPANILVMGEGPE
  189-  203 (28.67/17.82)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14649 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQNQHQQPTAPAPQAAAPPQAPPPQQSSTQTNGTTGGVAAGMGATAAGLQHSQDSGLSQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLTYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
353
501










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLGP
2) QYHPSHQAHRY
3) SRLTYQSSV
4) TLGYS
436
491
462
479
443
501
470
483