<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14633

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLNVATTNEEISNVAYLVASSSSPATIDAFRRRIAVRHTGSSLLDSLLSSVHVAATSYIYLFRIIRGIQLDSFNDLDFNGLNVVESSSFSPQDIVFPTFPVKALRTVISHFLNAVRIRLLDDISHDASVLGRLNSGFLIAHSTASNEWSAPWAIMRPLVYCHLQVHLTSSRLLIHPLVIPTSFLPVTPSLTQGSPILLLPYATPAYFLASYKGPCSALSKQFKECFEGLGVSSWDPESYIIAWVSVENRQGEDKGVMIIYPTSLCVRSLFPNTSSLPHIPTLPATLQSSPQSTPSLPFLSVSSPTSVSAFRTLTISKSRDINRVAKEVGGYVDAVAKERERERERLKREREGVGTTVAQPSSAQVPHLYVQQQVQLQQQQQTQQQQMQQQQAQQQQQMLDFYPSPPQTNLMVPPPSGHVSPVAPVAAPMDVDPLPNPAPSQPSYEPFNSNWMDMEDWMNGLGDTVNVGNGGDRGMGIGMMDFEADFTEDDFSFFDDKPPPPMPAVTGLTPAAPLEDPHWEIEPTPDVGTGLPSPPAESVLNFRVDDIKVQMKVDTAGGLWDAIPFADSYRATDGKYNMGKFSSSPGRAEGWRKRYEKVTDPRLGVVKRLALKRAKSIDEPERDDWEAEWREGNPEPEEDSEGADDSDEDMESAGEEESVDDTEGERPCTPLPAWIPMGPALLPMHFRHEVMLPLSAPLRSGVVGGSSGVGAGVSSVPTPVSPGRVGKGKSLQVAAESLGKEIVENSVWAAVWDGVNSKGNPGGFGRTLWEKDVQVVGRLFSAVQDINAPVQLEKLFGLAGSSGTGNGSESRLEKLESPMLLVGKGDAVIQISPPALRFWDKLGLGPRSGKKDIQAFVVFDSLQEQMSDKISEWLVNLRTVYEGKHFGTVSFGQSQFCEQDMNGVVPIRYDSTLRKTLDAFIAGSSSPPRTSTIVFIVTSITTMTLLSPILRQLFSVVRKASASHPQMLFHFVPEQILYSESNSQVEDLCGSVYDRILVPVVRSMSRKLSSAGEVTKFLEDPAFVLARTSEESKVVYSGPKADATAMILGVMDKGTFLHVGYGVSECGKWIFASCNDQRGDGHDLGVWLTSKGGGEANEGEVDEMTFLVHKVWDFTARFAKKANIEWRIVIAKLGSMGEAELDAWTRHLENDTEMGPVHVSVVAVEPSTPWMFTSRPEFDAPKSVSPSLKSIGRSASVSSSKPSKHNSHPVFVDMAFSTYALFQQSPLPVSVPPTLSDMGLDLGHIPDPSPWHGGEETHPQSPSIEHDHSNLPHVLPLIPHASSTLIRVPSSTTVATTTMLHIHLLHMIRSVGCSYPASDYNRLLRDITHSYYALSVLSSLKWRMKGVNPILPSHLGAVEAMRTAVVSGGSTDTPDS
Length1377
PositionKinase
OrganismArmillaria ostoyae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Armillaria.
Aromaticity0.08
Grand average of hydropathy-0.226
Instability index51.47
Isoelectric point5.39
Molecular weight150314.28
Publications
PubMed=29085064

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP14633
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.04|      24|      87|     414|     437|       1
---------------------------------------------------------------------------
  414-  437 (47.02/25.85)	PPP.....SGHVS.PVAPVAAP.MDVDPLPN
  499-  527 (34.67/16.97)	PPPpmpavTG.LT.PAAPLEDPhWEIEPTPD
  535-  555 (21.35/ 7.39)	PPA.....ESVLNfRVDDIKVQ.MKVD....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.49|      40|      43|     764|     804|       2
---------------------------------------------------------------------------
  764-  804 (65.33/43.26)	GFGRTL..WEKDVQVVGRlFSAVQDINAP.VQLEKLFGLAGSSG
  808-  850 (62.16/36.76)	GSESRLekLESPMLLVGK.GDAVIQISPPaLRFWDKLGLGPRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.64|     102|     336|     868|    1043|       3
---------------------------------------------------------------------------
  912- 1043 (129.66/210.18)	STLRKTLdAFIagsssPPRTSTIVFIVTSIT..TMTLLSPilrQLFSVVRKASASHPQmlfhfvpeqilySESNSQVEDLCGSVYdriLVPVVRSMSRKLSSAGEVTkfledPAFVLARTSEESKVVySGPKAD
 1270- 1373 (173.97/98.56)	SNLPHVL.PLI.....PHASSTLIRVPSSTTvaTTTMLHI...HLLHMIRSVGCSYPA............SDYNRLLRDITHSYY...ALSVLSSLKWRMKGVNPIL.....PSHLGAVEAMRTAVV.SGGSTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.55|      58|     121|     580|     638|       4
---------------------------------------------------------------------------
  580-  638 (99.50/49.18)	GKFSSSPGRAEGWRKRYEKVTDPRLGVVKRLALKrAKSIDEP..ERDDWEAEWREGNPEPE
  702-  761 (94.05/43.04)	GVVGGSSGVGAGVSSVPTPVSPGRVGKGKSLQVA.AESLGKEivENSVWAAVWDGVNSKGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.71|      38|     411|     448|     492|       5
---------------------------------------------------------------------------
  448-  492 (64.66/63.82)	FNSNWMDMED....WMNGLgDTVNvgnggdRGMGIGMMDF.EADFTEDDF
  860-  902 (62.05/41.55)	FDSLQEQMSDkiseWLVNL.RTVY......EGKHFGTVSFgQSQFCEQDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.74|      40|      47|    1168|    1210|      10
---------------------------------------------------------------------------
 1168- 1210 (68.09/40.22)	STPWMFTSRPefdAPKSVSPSLKSIGRS.ASVSSSKP..SKHNSHP
 1218- 1260 (66.65/32.60)	STYALFQQSP...LPVSVPPTLSDMGLDlGHIPDPSPwhGGEETHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14633 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDDFSFFDDKPPPPMPAVTGLTPAAPLEDPHWEIEPTPDVGTGLPSPPAESVL
2) SIDEPERDDWEAEWREGNPEPEEDSEGADDSDEDMESAGEEESVDDTEGERPCTPLPAW
3) VDAVAKERERERERLKREREGVGTTVAQPSSAQVPHLYVQQQVQLQQQQQTQQQQMQQQQAQQQQQMLDFYPSPPQTNLMVPPPSGHVSPVAPVAAPMDVDPLPNPAPSQPSYEPFNSNWMDMEDWMNGLGDTVNVGNGGDRGMGIGMMD
489
617
333
541
675
482










Molecular Recognition Features






MoRF SequenceStartStop




1) EADFT
484
488