<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14625

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceYPHHPQMHQGPPPGPHAMTMSMSPQQQLQLQQQQQQQQQQQQQQMMMLQPPVRQDMIPLARVIEFTCQKAYTDLNLLSELLHSKNDMERKIELVKYLSRVRYTLIRLLALVKWASGAGRVDQCDQIIAYLEEQSGLMFGTANWLMELAKGALTSARLPPFATIMAVDVFTQHTYTRLPACVKRLAGIPPAPIKPWEQRECLEQLDCLILYRLTITEIPTAMRQIKVYNGRAVLTVPHEFSVSLTLMSDSLSNPWRILNIKCLLRDLHTGRGKPLVHPLQMQWLHQRCQDRIISKDFDPRPPLVHLYDMLHSFCTFLQLDLLYEQACRLIRLRFGDLLAVEKYTAGSSLQLVYWRDLRRPATAGYRVRGHGLRLHTDPLDARRPICVTHFPDLPDSDATSIGRCIRSDELSLERLLDRTIQCRCRDLLYRAYKLLALLVAEPPARSAESLTLSLLQPAATHERLSIGVNAYRGLYSVRLPASGGRPCPHVAELEDRLNEDQPSLRRVALALAGLRAWLLCRRVRALFPDRRVASSLPTAKPLPSALASVIGPAQHACFVQLHRYQNNYLALVPTGGLNPSFACFYVTGSAHAGYYIRPAKICPMRPPDLSLPSRTDPSASDPLAVLARRRRTKLLSAPRPDQFSLLRAAWLTDYVDLIEEDHLLHQVMCELARSGLPHREFAPDSAGMSALTLHSLPTPPGISAEAAAHASSLVQSLTLRLYRSGQYQPPVNFRVPPPRASLVALVREWRLSGCPLDPPERRVRTCPPCVHLGVNELGPSSRCAEAVGSVQSEWQQLCHLVQMCLPLTRRSNWPPDTCLVSFGFPGLRIAYGPVRDEEGVPVWEMHMIQKAAAGQKPDIYINFVSRRPSAPNPHFPVREQLSKDFLRHHSVLHLLRQLASSYRALAPLACLAGGWHISPQLTCCRQTVLLAHPYRLQLEHRGRVTLSVRLDADNCVRLASPQLTPLQLIRLHPAARIDSDQSVALPAADWADLRPYHWLACACQFLALCQSCERQQQQRHELLDDGCLLTLRTERLGCLNVRLCLEGVLCHVDAGEPALATFVQRLLFHPPYRWQAVASLQALLCSPGALRACLCLEDPRLLPPPNKPLLTQLQLLTVKDYPSTQFYRLGMPAVGIYLLHDQRPELYFSLLLTDSESRRCLSIMILYDELKNDAKLFNPFAASGGGGLIAAALMRLDAEAIKPVQTACSGEGRECSLPHLFRAIASGRWIQ
Length1230
PositionTail
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.129
Instability index57.16
Isoelectric point9.04
Molecular weight138315.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14625
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1146.89|     283|     286|     516|     801|       1
---------------------------------------------------------------------------
    7-  241 (160.19/66.86)	................................................................................................................................................MHQGP.P...PG..PHAMTMSMSPQQQLQLqqqQQQQQ..QQQQQQMMMLQPP.VRQDMIPLA...RVIEFT.C..Q............................KAYT.....................................DLNLLSELLH.SKNDMERKIELVKYLSRVRYTLIRLLALVKwasgagrvdqcdqiiayleeqsglmfgtanWLMelakgaltsarlppfatIMAV.DVFT.QHTYTRLPACVKRLAG....IPPAPIKPwEQRECLE...QLdclilyrltiteiptamrqiKVYNGR........AVLTV...PH...EFSV
  242-  580 (357.65/164.58)	SLTLMSDSLSNPWRILNIK.CLLR..DLH.TG..............RGKPLV.HPLQMqwLHQRCQDRIISKdfdPR..PPLVHLY..DMLHSFCTFLQLD.LL.....YEQACR.LIrlRFGdlLAVEKYTAGSS.LQLVY..WRDLRRP...........ATAGYRVRGHGL...RLHTDplDARRPICVTHFPDlPDSDATSIG...RCIRSDELSLErlldrtiqcrcrdllyraykllallvaePPARsaesltlsllqpaatherlsigvnayrglysvrlpasGGRPCP...H..VAEL..EDRLNEDQPSLRRVALALAGLRA..............................WLL.................CRRVrALFP.DRRVASSLPTAKPLPS....ALASVIGP.AQHACFV...QL....................HRYQNN........YLALV...PTGGlNPSF
  581-  874 (445.48/202.59)	ACFYVTGSAHAGYYIRPAKICPMRPPDLSLPS..............RTDPSASDPLAV..LARRRRTKLLSA...PR..PDQFSLLRAAWLTDYVDLIEEDHLL.....HQVMCE.LA..RSG..LPHREFAPDSAGMSALT..LHSLPTP...PGISAEAAAHASSLVQSLTL...RLYRS..GQYQPPVNFRVPP.PRASLVALV...REWRLSGCPLD............................PPER.....................................RVRTCPPCVHlGVNELGPSSRCAEAVGSVQSEWQQLCHLVQ..............................MCL.........................PlTRR..SNWPPDTCLVSfgfpGLRIAYGP.VRDEEGVpvwEM....................HMIQKAaagqkpdiYINFVsrrPSAP.NPHF
  908- 1103 (183.57/77.20)	AC..LAG....GWHISPQLTCCRQTVLLAHPYrlqlehrgrvtlsvRLDADNCVRLASpqLTPLQLIRLHPA...ARidSDQSVALPAA...DWADL.RPYHWLacacqFLALCQsCE..RQQ..QQRHELLDDGCLLTLRTerLGCLNVRlclEGVLCHVDAGEPALA.TFVQ...RLL......FHPPYRWQA....VASLQALLcspGALRACLCLED............................P..........................................RLLPP..........................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.76|      13|     470|     424|     437|       2
---------------------------------------------------------------------------
  424-  437 (17.90/11.79)	RDLLyRAYKLLALL
  882-  894 (22.86/10.10)	KDFL.RHHSVLHLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14625 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPHHPQMHQGPPPGPHAMTMSMSPQQQLQLQQQQQQQQQQQQQQMMML
1
48










Molecular Recognition Features






MoRF SequenceStartStop




NANANA