<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14623

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceHHPQMHQGPPPGPHAMTMSMSPQQQLQLQQQQQQQQQQQQQQMMMLQPPVRQDMIPLARVIEFTCQKAYTDLNLLSELLHSKNDMERKIELVKYLSRVRYTLIRLLALVKWASGAGRVDQCDQIIAYLEEQSGLMFGTANWLMELAKGALTSARLPPFATIMAVDVFTQHTYTRLPACVKRLAGIPPAPIKPWEQRECLEQLDCLILYRLTITEIPTAMRQIKVYNGRAVLTVPHEFSVSLTLMSDSLSNPWRILNIKCLLRDLHTGRGKPLVHPLQMQWLHQRCQDRIISKDFDPRPPLVHLYDMLHSFCTFLQLDLLYEQACRLIRLRFGDLLAVEKYTAGSSLQLVYWRDLRRPATAGYRVRGHGLRLHTDPLDARRPICVTHFPDLPDSDATSIGRCIRSDELSLERLLDRTIQCRCRDLLYRAYKLLALLVAEPPARSAESLTLSLLQPAATHERLSIGVNAYRGLYSVRLPASGGRPCPHVAELEDRLNEDQPSLRRVALALAGLRAWLLCRRVRTLFPDRRVASSLPTAKPLPSALASVIGPAQHACFVQLHRYQNNYLALVPTGGLNPSFACFYVTGSAHAGYYIRPAKICPMRPPDLSLPSRTDPSASDPLAVLARRRRTKLLSAPRPDQFSLLRAAWLTDYVDLIEEDHLLHQVMCELARSGLPHREFAPDSAGMSALTLHSLPTPPGISAEAAAHASSLVQSLTLRLYRSGQYQPPVNFRVPPPRASLVALVREWRLSGCPLDPPERRVRTCPPCVHLGVNELGPSSRCAEAVGSVQSEWQQLCHLVQMCLPLTRRSNWPPDTCLVSFGFPGLRIAYGPVRDEEGVPVWEMHMIQKAAAGQKPDIYINFVSRRPSAPNPHFPVREQLSKDFLRHHSVLHLLRQLASSYRALAPLACLAGGWHISPQLTCCRQTVLLAHPYRLQLEHRGRVTLSVRLDADNCVRLASPQLTPLQLIRLHPAARIDSDQSVALPAADWADLRPHHWLACACQFLALCQSCERQQQQRHELLDDGCLLTLRTERLGCLNVRLCLEGVLCHVDAGEPALATFVQRLLFHPPYRWQAVASLQALLCSPGALRACLCLEDPRLLPPPNKPLLTQLQLLTVKDYPSTQFYRLGMPAVGIYLLHDQRPELYFSLLLTDSESRRCLSIMILYDELKNDAKLFNPFAASGGGGLIAAALMRLDAEAIKPVQTACGGEGRECSLPHLFRAIASGRWIQ
Length1228
PositionTail
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.130
Instability index57.14
Isoelectric point9.04
Molecular weight138028.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14623
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     318.35|      87|      97|     389|     484|       1
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  317-  383 (49.67/18.56)	........................................DLLYeqacrlirlRFGDLLA..VEKYTAGS..SLQLvywrDLRRPATAGYR....V...RG.HGLRLhtdPLDARRP..iC
  389-  484 (140.98/87.80)	DLPDSdatsigrcIRSDELSLERL......LDRTIQCRCRDLLY.........RAYKLLALLVAEPPARSAESLTL....SLLQPAATHERLsIGVNAYRGLYSVRL...PASGGRP...C
  489-  580 (127.70/63.99)	ELEDR........LNEDQPSLRRValalagLRAWLLCRRVRTLF.........PDRRVASSL...PTAKPLPSALA....SVIGP.AQHACF.VQLHRYQNNYLALV...PTGGLNPsfaC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.41|      14|      41|     915|     930|       2
---------------------------------------------------------------------------
  915-  930 (21.23/20.23)	SPQLTCCrQTVLLaHP
  957-  970 (28.17/15.67)	SPQLTPL.QLIRL.HP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.02|      66|     338|     634|     765|       3
---------------------------------------------------------------------------
    5-   59 (85.71/26.09)	MHQGP.PPG..PHAMTMSMSPQQQLQLqqqQQQQQQQQQQQMMMLQPPVRQDMIPLAR...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  599-  614 ( 0.63/44.40)	..........................................................vieftcqkaytdlnllsellhskndmerkielvkylsrvrytlirllalvkwasgagrvdqcdqiiayleeqsglmfgtanwlmelakgaltsarlppfatimavdvftqhtytrlpacvkrlagippapikpweqrecleqldclilyrltiteiptamrqikvyngravltvphefsvsltlmsdslsnpwrilnikcllrdlhtgrgkplvhplqmqwlhqrcqdriiskdfdprpplvhlydmlhsfctflqldllyeqacrlirlrfgdllavekytagsslqlvywrdlrrpatagyrvrghglrlhtdpldarrpicvthfpdlpdsdatsigrcirsdelslerlldrtiqcrcrdllyraykllallvaepparsaesltlsllqpaatherlsigvnayrglysvrlpasggrpcphvaeledrlnedqpslrrvalalaglrawllcrrvrtlfpdrrvasslptakplpsalasvigpaqhacfvqlhryqnnylalvptgglnpsfacfyvtgsahagyyirpakiCPMRPPDLSLpsRTDP
  690-  764 (106.68/57.81)	LHSLPtPPGisAEAAAHASSLVQSLTL...RLYRSGQYQPPVNFRVPPPRASLVALVR.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ewrlsgCPLDPPERRV..RTCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.93|      40|      44|     776|     819|       4
---------------------------------------------------------------------------
  776-  815 (80.76/30.68)	PSSRCAEAVGSVQSE.....WQQLCH..LVQMCLPLTR.RSNWPPDTC
  822-  846 (22.24/ 6.05)	PGLRI..AYGPVRDEegvpvWEM..H..MIQ.................
 1067- 1105 (57.93/19.54)	PPYR.WQAVASLQA........LLCSpgALRACLCLEDpRLLPPPNKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.64|      20|     338|     634|     661|       5
---------------------------------------------------------------------------
  638-  661 (26.09/38.73)	DQFSLLRAAwltDYVDLiEEDHLL
  977-  996 (40.54/22.42)	DQSVALPAA...DWADL.RPHHWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.81|      20|      29|     169|     196|       8
---------------------------------------------------------------------------
  169-  196 (31.31/30.23)	QHTYTRLPACVKRlagippapIKPWEQR
  209-  228 (34.50/16.43)	RLTITEIPTAMRQ........IKVYNGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.00|      43|     284|     852|     914|      10
---------------------------------------------------------------------------
  852-  914 (66.67/67.81)	QKPDIYINFV.....SRRpsapnphfpvreqlskdflrHHSVLHLLRQLASSYRALAPLACLAGGWHI
 1139- 1186 (70.33/37.22)	QRPELYFSLLltdseSRR....................CLSIMILYDELKNDAKLFNPFAASGGGGLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14623 with Med14 domain of Kingdom Metazoa
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