<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14622

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceRANMYPHHPQMHQGPPPGPHAMTMSMSPQQQLQLQQQQQQQQQQQQQQMMMLQPPVRQDMIPLARVIEFTCQKAYTDLNLLSELLHSKNDMERKIELVKYLSRVRYTLIRLLALVKWASGAGRVDQCDQIIAYLEEQSGLMFGTANWLMELAKGALTSARLPPFATIMAVDVFTQHTYTRLPACVKRLAGIPPAPIKPWEQRECLEQLDCLILYRLTITEIPTAMRQIKVYNGRAVLTVPHEFSVSLTLMSDSLSNPWRILNIKCLLRDLHTGRGKPLVHPLQMQWLHQRCQDRIISKDFDPRPPLVHLYDMLHSFCTFLQLDLLYEQACRLIRLRFGDLLAVEKYTAGSSLQLVYWRDLRRPATAGYRVRGHGLRLHTDPLDARRPICVTHFPDLPDSDATSIGRCIRSDELSLERLLDRTIQCRCRDLLYRAYKLLALLVAEPPARSAESLTLSLLQPAATHERLSIGVNAYRGLYSVRLPASGGRPCPHVAELEDRLNEDQPSLRRVALALAGLRAWLLCRRVRALFPDRRVASSLPTAKPLPSALASVIGPAQHACFVQLHRYQNNYLALVPTGGLNPSFACFYVTGSAHAGYYIRPAKICPMRPPDLSLPSRTDPSASDPLAVLARRRRTKLLSAPRPDQFSLLRAAWLTDYVDLIEEDHLLHQVMCELARSGLPHREFAPDSTGMSALTLHSLPTPPGISVEAAAHASSLVQSLTLRLYRSGQYQPPVNFRVPPPRASLVALVREWRLSGCPLDPPERRVRTCPPCVHLGVNELGPSSRCAEAVGSVQSEWQQLCHLVQMCLPLTRRSNWPPDTCLVSFGFPGLRIAYGPVRDEEGVPVWEMHMIQKAAAGQKPDIYINFVSRRPSAPNPHFPVREQLSKDFLRHHSVLHLLRQLASSYQALAPLACLAGGWHISPQLTCCRQTVLLAHPYRLQLEHRGRVTLSVRLDADNCVRLASPQLTPLQLIRLHPAARIDSDQSVALPAADWADLRPHHWLACACQFLALCQSCERQQQQRHELLDDGCLLTLRTERLGCLNVRLCLEGVLCHVDAGEPALATFVQRLLFHPPYRWQAVASLQALLCSPGALRACLCLEDPRLLPPPNKPLLTQLQLLTVKDYPSTQFYRLGMPAVGIYLLHDQRPELYFSLLLTDSESRRCLSIMILYDELKNDAKLFNPFAASGGGGLIAAALMRLDAEAIKPVQTACGGEGRECSLPHLFRAIASGRWIQ
Length1234
PositionTail
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.133
Instability index57.27
Isoelectric point9.04
Molecular weight138761.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14622
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     376.65|      95|      97|     395|     490|       1
---------------------------------------------------------------------------
  323-  389 (45.53/20.81)	........................................................................D.LLYeqacrlirlRFGD.....LLA.....VEKYTAGS............SLQLvywrDLRRPATAGYR....V...R.G.HGLRLhtdPLDARRP..iC
  395-  490 (161.91/100.55)	DL............................PDSDATSIGRCI.RSDELSL..ERL......LDRTIQCR.CRD.LLY.........RAYK.....LLALL...VAEPPARSAE..........SLTL....SLLQPAATHERLsIGVNAYR.GLYSVRL...PASGGRP...C
  495-  586 (120.57/69.69)	EL............................EDR........L.NEDQPSL..RRValalagLRAWLLCR.RVR.ALF.........PDRR.....VASSL......PTAKPLP..........SALA....SVIGP.AQHACF.VQLHRYQ.NNYLALV...PTGGLNPsfaC
  611-  730 (48.64/22.83)	DLslpsrtdpsasdplavlarrrrtkllsaPRPDQFSLLRAAwLTDYVDLieEDH......LLHQVMCElARSgLPH.........REFApdstgMSALTlhsLPTPPGISVEaaahasslvqSLTL....RL................YRsGQY..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.99|      40|      44|     749|     791|       2
---------------------------------------------------------------------------
  732-  761 (45.87/21.05)	........PP....VNFRV....PPPR.ASLVA......lVR.EWRLSGCPLDP
  762-  805 (59.81/39.03)	PERRVRTCPP..C.VHLGVneLgPSSRCAEAVG......sVQsEWQ.QLCHLVQ
  809-  848 (39.31/16.96)	PLTRRSNWPPdtClVSFG...F.PGLRI..AYGpvrdeegVP.VWEM.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.93|      13|     286|     858|     870|       3
---------------------------------------------------------------------------
  858-  870 (24.82/14.22)	QKPDIYINFV.....SRR
 1145- 1162 (18.12/ 8.51)	QRPELYFSLLltdseSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.77|      54|     136|     913|     968|       4
---------------------------------------------------------------------------
  913-  968 (92.27/42.25)	CLAGGW................HISPqlTCCRQ....TVLLAHPYRLQL..EHRGRVTLSVRLDADNC.VRLASPQLTP
  988- 1063 (59.07/22.09)	LPAADWadlrphhwlacacqflALCQ..SCERQqqqrHELLDDGCLLTLrtERLGCLNVRLCLEGVLChVDAGEPALA.
 1067- 1106 (57.43/20.89)	................................Q....RLLFHPPYRWQA..VASLQALLCSPGALRAC.LCLEDPRLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.33|      23|      25|     264|     288|       5
---------------------------------------------------------------------------
  264-  288 (39.15/30.72)	KCLLRDLHT..GRGKPLVHPLQMqwLH
  290-  314 (40.18/23.32)	RCQDRIISKdfDPRPPLVHLYDM..LH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.81|      20|      29|     175|     202|       6
---------------------------------------------------------------------------
  175-  202 (31.31/34.86)	QHTYTRLPACVKRlagippapIKPWEQR
  215-  234 (34.50/18.94)	RLTITEIPTAMRQ........IKVYNGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.10|      25|      29|      10|      36|       7
---------------------------------------------------------------------------
   10-   34 (48.18/27.75)	QMHQGPPPGPHAMTMSMSP..QQQLQL
   37-   63 (41.92/17.74)	QQQQQQQQQQQQMMMLQPPvrQDMIPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14622 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RANMYPHHPQMHQGPPPGPHAMTMSMSPQQQLQLQQQQQQQQQQQQQQMMML
1
52










Molecular Recognition Features






MoRF SequenceStartStop




NANANA