<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14606

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceSKLSSQLRAALAADSPANAVPVSPDSNGSGLSLDESSGISDREALSSQEQTMQYSEVDAKSVHSSDSEDEPVQNPLPEVPAGCGPHTVQLSVLLDFAIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKAVCSRLNQLIETRLSRLSSGIPPNIREIHIKNGLATLLVPGEFEIKITLLGETEMIKWTLLNIKILVEDYELGMGLPLVHPLQLNQIHGVLQSRMNVAANPIKEAFFFLHSFCVSLQLDVLYCQTSRMAAGRLRENIVIEKYDPKERVLVVGYWVKRSKNKKLTVGQLKVDAQYRVQIYEDKDDKLGGLKVRHFPHAPQLGTIDCNAGMLSMDRLLSETFDVRCKERLMRLRRLLEAAEPLLEVKMTGLSVPSLSLTLLPDTTSTEEMLTVSVNSFCGKVICNVNMLSSENEDVLAFARALYSSRCSDTTIRSYLAKLRVSIVIERYRRSVKALPIYEVRETELFPFVKEVLRETPAQRLVLRYLRSENYYLIVSFQPDEKEVVSTKLLLLEVDEDRAQFIPLDNDRDVYDVNVAEAVAQGTLKFADLHKISLQKECSREQRLAFAIATIEDRLTYMYVAAELDKKGVGVDLRKDDVHVPGGLALHITDVSSVVPFDAAQFFECCVRSCLRLDNRNRYTFQFEMCFENIPLVRDVPHGLAHRRDGDHETTWVQEINQINQITPDKIVEGIIHRLMRYLYMYKVVFQFSQAYNRYFKSFCSIEAYTFHKLVVSYGENRDMLMVLAFNVKSQTPGSSEDYFLMNFGQTMPHKQFNAAEIDWHQKPRWNPHVMMAQLLRDQLKETSDLVYIMHYLCETIRPLAALGNFVRIRFQSLKSLSQLIGPEVHFPFRLKYHLTPIDHFTLRLMHGNVILEIKMLREMKIAVRDVSRYQPRCAGLFQLFSNIDSETTQLLAEELPIPQSDCEHAAGPKMWTKDQFMETIDDRYEEPDARMAVTTQPVLMTHDTIIKACDFQEIDGRVTCPLDEYLNSIFYLQRALLTLERMSPRANPSQNSNNNLFSGYVTVVDSRPEHIRFRALQLNGDGLNATSMVHYKIYLCPIAMTLKISIDYDEGTNCEATPENLETLATYFEKIVFRCGDEYALQSYVLMTRVTSYGATKSIANLMNAQMGITPTSKCCMQLSLTYNNTSTKKLAPATKVDQQLNNIIFNIRFKVIISQSRTSESFSILRFIYRIKENMVTTPSVEIKQMADDVNAETKSSGQCAIWALVSLVSDRFRSGVWNPSNRDEPIISSVAPTANYANPGSVAAPGSIAPGSVAPGSVAPASQQPGSIMQPGSMMGPQSVNAHQYGMHRQMGGPPSMQMNPSSVGPQPGSVGMPGSVGGPGSMMNPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGHPNYPQWNPPPGGQYHPHHMPYPPQ
Length1515
PositionTail
OrganismCaenorhabditis latens
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.229
Instability index43.64
Isoelectric point6.51
Molecular weight170552.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     224.22|      23|      25|    1441|    1463|       1
---------------------------------------------------------------------------
 1378- 1397 (35.24/17.91)	A...PGSIA.PGSV.APGS..VAPAS..Q
 1398- 1414 (34.03/17.01)	Q.........PGSIMQPGSM.MGPQS..V
 1417- 1438 (35.20/17.88)	H.....QYGMHRQMGGPPSMqMNPSS..V
 1441- 1463 (53.17/31.20)	Q...PGSVGMPGSVGGPGSM.MNPGS..H
 1466- 1491 (37.39/19.50)	HmmnPGSVG.PGSVGGPGS..VNPGSvgH
 1493- 1513 (29.18/13.41)	N..yPQWNPPPGGQYHPHHM.PYP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.29|      11|      75|     433|     443|       2
---------------------------------------------------------------------------
  433-  443 (21.93/16.80)	GTIDCNAGMLS
  510-  520 (21.36/16.13)	GKVICNVNMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.06|      35|     117|     186|     220|       4
---------------------------------------------------------------------------
  186-  220 (59.82/41.53)	DLELAR.LPEYHIAP....AIDVLVLGTYNRMPSKIKEAF
  301-  338 (48.02/31.70)	DYELGMgLPLVH..PlqlnQIHGVLQSRMNVAANPIKEAF
  341-  367 (32.22/18.54)	.......LHSFCVSL....QLDVLYCQTSRMAAGRLRE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     204.38|      52|     120|    1052|    1106|       5
---------------------------------------------------------------------------
 1012- 1034 (21.30/ 7.70)	............................................FS.NIDSETT..........QLLAEE.L..PIPQSDC
 1053- 1106 (89.02/72.63)	DdrYEEPDARMAVTTQP..............VLMTHDTIIKACDFQ.EIDGRVT..........CPLDEY.LN.SIFYLQR
 1112- 1178 (28.10/13.27)	........ERMSPRANPsqnsnnnlfsgyvtVVDSRPEHIRFRALQlNGDGLNAtsmvhykiylCPIAMT.LKiSI.....
 1179- 1221 (65.95/41.67)	D..YDEGTNCEAT...P..............ENL..ETL..ATYFE.KIVFR............CG.DEYaLQ.SYVLMTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      16|      17|     722|     737|       6
---------------------------------------------------------------------------
  722-  737 (31.40/21.51)	VSSVVPFDAAQ...F.FECC
  738-  757 (22.37/13.06)	VRSCLRLDNRNrytFqFEMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      18|      18|     385|     402|       9
---------------------------------------------------------------------------
  385-  402 (31.49/25.05)	YWVKRSKNKKLTVGQLKV
  406-  423 (31.35/24.90)	YRVQIYEDKDDKLGGLKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14606 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADSPANAVPVSPDSNGSGLSLDESSGISDREALSSQEQTMQYSEVDAKSVHSSDSEDEPVQNPLPEVPA
2) NPGSVAAPGSIAPGSVAPGSVAPASQQPGSIMQPGSMMGPQSVNAHQYGMHRQMGGPPSMQMNPSSVGPQPGSVGMPGSVGGPGSMMNPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGHPNYPQWNPPPGGQYHPHHMPYPPQ
13
1372
81
1515










Molecular Recognition Features






MoRF SequenceStartStop




1) SKLSSQLRAALAADSPANAV
1
20