<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14605

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceSKLSSQLRAALAADSPANAVPVSPDSNGSGLSLDESSGISDREALSSQEQTMQYSEVDAKSVHSSDSEDEPVQNPLPEVPAGCGPHTVQLSVLLDFAIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKAVCSRLNQLIETRLSRLSSGIPPNIREIHIKNGLATLLVPGEFEIKITLLGETEMIKWTLLNIKILVEDYELGMGLPLVHPLQLNQIHGVLQSRMNVAANPIKEAFFFLHSFCVSLQLDVLYCQTSRMAAGRLRENIVIEKYDPKERVLVVGYWVKRSKNKKLTVGQLKVDAQYRVQIYEDKDDKLGGLKVRHFPHAPQLGTIDCNAGMLSMDRLLSETFDVRCKERLMRLRRLLEAAEPLLEVKMTGLSVPSLSLTLLPDTTSTEEMLTVSVNSFCGKVICNVNMLSSENEDVLAFARALYSSRCSDTTIRSYLAKLRVSIVIERYRRSVKALPIYEVRETELFPFVKEVLRETPAQRLVLRYLRSENYYLIVSFQPDEKEVVSTKLLLLEVDEDRAQFIPLDNDRDVYDVNVAEAVAQGTLKFADLHKISLQKECSREQRLAFAIATIEDRLTYMYVAAELDKKGVGVDLRKDDVHVPGGLALHITDVSSVVPFDAAQFFECCVRSCLRLDNRNRYTFQFEMCFENIPLVRDVPHGLAHRRDGDHETTWVQEINQINQITPDKIVEGIIHRLMRYLYMYKVVFQFSQAYNRYFKSFCSIEAYTFHKLVVSYGENRDMLMVLAFNVKSQTPGSSEDYFLMNFGQTMPHKQFNAAEIDWHQKPRWNPHVMMAQLLRDQLKETSDLVYIMHYLCETIRPLAALGNFVRIRFQSLKSLSQLIGPEVHFPFRLKYHLTPIDHFTLRLMHGNVILEIKMLREMKIAVRDVSRYQPRCAGLFQLFSNIDSETTQLLAEELPIPQSDCEHAAGPKMWTKDQFMETIDDRYEEPDARMAVTTQPVLMTHDTIIKACDFQEIDGRVTCPLDEYLNSIFYLQRALLTLERMSPRANPSQNSNNNLFSGYVTVVDSRPEHIRFRALQLNGDGLNATSMVHYKIYLCPIAMTLKISIDYDEGTNCEATPENLETLATYFEKIVFRCGDEYALQSYVLMTRVTSYGATKSIANLMNAQMGITPTSKCCMQLSLTYNNTSTKKLAPATKVDQQLNNIIFNVIISQSRTSESFSILRFIYRIKENMVTTPSVEIKQMADDVNAETKSSGQCAIWALVSLVSDRFRSGVWNPSNRDEPIISSVAPTANYANPGSVAAPGSIAPGSVAPGSVAPASQQPGSIMQPGSMMGPQSVNAHQYGMHRQMGGPPSMQMNPSSVGPQPGSVGMPGSVGGPGSMMNPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGHPNYPQWNPPPGGQYHPHHMPYPPQ
Length1511
PositionTail
OrganismCaenorhabditis latens
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.229
Instability index43.59
Isoelectric point6.41
Molecular weight170008.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     243.06|      23|      25|    1437|    1459|       1
---------------------------------------------------------------------------
 1349- 1373 (18.84/ 6.25)	....PSNRDEPiiSSVAPTANY.ANPGS.vA
 1374- 1393 (35.24/19.33)	A...PGSIA.P..GSV.APGS..VAPAS..Q
 1394- 1410 (34.03/18.37)	Q.........P..GSIMQPGSM.MGPQS..V
 1413- 1434 (35.20/19.31)	H.....QYGMH..RQMGGPPSMqMNPSS..V
 1437- 1459 (53.17/33.64)	Q...PGSVGMP..GSVGGPGSM.MNPGS..H
 1462- 1487 (37.39/21.05)	HmmnPGSVG.P..GSVGGPGS..VNPGSvgH
 1489- 1509 (29.18/14.50)	N..yPQWNPPP..GGQYHPHHM.PYP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.29|      11|      75|     433|     443|       2
---------------------------------------------------------------------------
  433-  443 (21.93/12.71)	GTIDCNAGMLS
  510-  520 (21.36/12.20)	GKVICNVNMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.06|      35|     117|     186|     220|       3
---------------------------------------------------------------------------
  186-  220 (59.82/36.79)	DLELAR.LPEYHIAP....AIDVLVLGTYNRMPSKIKEAF
  301-  338 (48.02/28.05)	DYELGMgLPLVH..PlqlnQIHGVLQSRMNVAANPIKEAF
  341-  367 (32.22/16.34)	.......LHSFCVSL....QLDVLYCQTSRMAAGRLRE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     206.31|      52|     120|    1052|    1106|       5
---------------------------------------------------------------------------
 1012- 1034 (21.30/ 7.95)	............................................FS.NIDSETT..........QLLAEE.L..PIPQSDC
 1053- 1106 (88.49/74.09)	DdrYEEPDARMAVTTQP..............VLMTHDTIIKACDFQ.EIDGRVT..........CPLDEY.LN.SIFYLQR
 1110- 1178 (31.04/16.13)	......TLERMSPRANPsqnsnnnlfsgyvtVVDSRPEHIRFRALQlNGDGLNAtsmvhykiylCPIAMT.LKiSI.....
 1179- 1221 (65.48/42.38)	D..YDEGTNCEAT...P..............ENL..ETL..ATYFE.KIVFR............CG.DEYaLQ.SYVLMTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      16|      17|     722|     737|       6
---------------------------------------------------------------------------
  722-  737 (31.40/20.21)	VSSVVPFDAAQ...F.FECC
  738-  757 (22.37/12.21)	VRSCLRLDNRNrytFqFEMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.05|      16|      16|     928|     943|       8
---------------------------------------------------------------------------
  928-  943 (27.63/16.03)	IRPLAAL.GNFVRIRFQ
  945-  961 (24.42/13.33)	LKSLSQLiGPEVHFPFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      18|      18|     385|     402|      14
---------------------------------------------------------------------------
  385-  402 (31.49/24.71)	YWVKRSKNKKLTVGQLKV
  406-  423 (31.35/24.56)	YRVQIYEDKDDKLGGLKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14605 with Med14 domain of Kingdom Metazoa
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