<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14603

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMGRAWNDSGVVKCTFVTDNKIYSGPDVGGSIQLLVIDPGEKPRPFHYDWISTKKMDDLLVLCKIAGAKEAHAPEKDKEKSSVGNVMSTPKNISPVGFDQFVALWYRHGKPIMGRAWPKNGRIEASFVDSNREFTGATVGSLQLLISLPPTTVGYDYVWMAYGQAVDYRDKDYVPVHLSYICPAVVPVNGKLILGQVNMKTECATVALDGTVTQLDGGPVKSFSKVSSQQNQPLYSEASRIPAGSGPARDSSEDMLSSKEGDKDALKNKLKNAKRPEFINGGSLEDCLSNVYSLLELPGIKWKCFRTKPNAPRGVPLTSDLVLKAYSRCVLDGILCTWRRKPSAPTDNDELLPATHFFSNDSPKELWVFWYDDEPTDLPKLCEGLESDEELSSANQMNIVSYEVRTLIFKALHVVLERDLTKDGHFDCKPPKRFPVVVGPWSMRGYLIQDQMTLLADPKIQEAAEKEWNQWKEYLQLEEKEPESVVEERQKSPDSEPTTAPPPAPRVLLASSSDEEQPKSDGNDDVANDSIPQKFRWMYEPDYRQEKPKEETPEEREKRMQAREVRRIRRKNREERLKELERQRAETTNAEDYDSDVVTDVEVEVKEESVSSEVPRMILIEIDNVRLLYPSKFICITVEEDRQMLESMGLKTHPPPQELQVQGRRPRNKNVVSASNPILSTMAVYQYCERQRMIDRERLNKENAHDDKYLDAHSRVAFAYWKEKTDKKEKIEKAPSPPPYELYKHKESYLSWKSARPAYLMSYRPRVRSHMPTYDPKNDEETFNKEWECYQALATARMKSKISRKKFESEMAYNNFLKKKKTRLKQIGEKRRSKRSRPSGSIRAESEDEAYQMDKLSQQDWANLEDDHPKVIPEIEVEKEELFNDIKLPKVPNDDTYKPKPFFPVSLLTTVSSRSELIPLAGDDEMSEERFNAVFKDPKGLRGFEAICAKKEEIESVKKEKWLKKHRRKESKRQIKTARDCHLEMEKQLVKRSLKRSLKKLRISAKKDSLSDPVIQEEELDPLLLNRVDVKALDKSVKLMENELDQMNMNTFCINREKAGPHGVPSTSGFIPADYTLSPHRSFEEESDSEIDEQRTGLGEGTSDQYEEGESVDMVEPDREQIPDHSVDFANIGHIRTVGDHIGPDGLLSPPASNEMPKGGPLSVGPPSIESQGLNQIYPTPPSVQMLQENAAQGHSPVMMHGKSRYTANASDEDIERVDVPGGCGKIVEIPDDDCETKHMKTLNKLVNQPKLTNFLVSSCHNPILKGRKVRYDTPITDKFKLQNETEKVTAELVYEPMVKRNFECPPPRTFGVLAQKKRSGKRAPLPSSLPSTFSALNPGFANPMGPPIFQSPTLPPHHIQSPFSMGPMGHHPMGHPNYPATPGPFPPTTPTYPGMTPRPGSNFGPGFGYPNQQMMPPAYSNQMGSMGQMGQMGQMGQMGQMGPMGQLGVQRQFSNPQMYQHQMQMRMQQMRQMSGQGGPPGYGGPGVPPFQSPVTPGPGGFGMSTGPSSVQRLNNFVNQSQFGPSSGQSYGSIPPMIPQSPNFNQPFPGMGNAMMSPMQQHQFHHQQMMQQHQQQHQHQQQHQLQMQRNQAQTQNPQTNSQQAVQPFQPSAQFLQQQQYEQVNAAFNQLSDREKQKFNRRQIQLLHGIMPTSLQPATIKALRNPPDANIPFKKPDPIYRHPDLNIPRGDSLTIAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDLGMYITPHMVLSSRERGQTNMREYTVGTWSGFHVNSATNCTCGFSAIRHRYLSCCSGLFEEDADEATTSEHAMAPVIPPLNYPKRATGRDMTWFDSKSVHDMALLNQIRQMAFSNSIGKAVSQMASGAEHARNVSIAMDIGTDVTVPSEYILSHVDTLELLMLGMSALGPMQKSGIGNQIASQNKFLSYFHPWGFQTANEITELEASEWVDLLGIVTPTLEVSMKHARHLPPEAPTTVEGPMTWKQIVTKAIRGKPLSDDDDDYSLTEPVPAVMRALTKEAIRAAPNIEQYSDQASLGPIDQPKDVMYITIIPDDPTIYEKAVEFMDNVTATYERMRLGRHIPFPVSTGTATKFRKVLEEQQNQFNFPEKPAQPEDEAKKAKDSKDFEDHFGREPVETELDFWIRRAKRKFDSYEDLKKTEDTDIPPPDSFDKEMSKNNVYRRRMSGFPFREDRYYEREGILRVGTPLERSRLQHTVTNTPEFENMTRHLNDKNGFVTKLRLYLQQMEDLVHHALTENAEAFERTGYRYQLAVEGRLKRRKHRKDLNEERLRYESAKLMEDEVLIAVQPEEADLCTGVEVGNEGSVPWVNDELQEQKELKQKENEQYPPEGHQAPSPVPAGMIHIPETLSKQERTVQPSLNDIFADPSTVAPMNAQNISWKKRDTHVPNPFPSSNQPPVAFEATGSLDTDAISTLPHVIVLYVVNPFSYGPEGHSAIHMRIAILAFIRAFNSIIGRLPFQKRPQLQLEIIGLESLDDVTKSIPDYFNDPKVPFDILHDNQTKFERTAEAEQAEIARSLSVAVYTHPRVFTPDVYKSVSARCMTAFGPGSQIINTINNIEKINQDSFFRMSKRSKMALETLDGFRHPGMMAPQQVEKKNYIAYRVPSNILCLAPPPPVYQMDEDGKPVLNQLDEQTLFISYCLVGADFLVATATDAQGKLIDNCVANIKPRRQRNQVYRYRNKTQILDGMGKLWSFILGVMSSDIKNWRLVVGRLGRIGHGEFRAWTHLLNKTSLLRYSGSLKDICSACRSMPTAVGTPAILSACLITLEPEPSIRIMPDFQDQSATTKKSYIFQTPGDLSCTHILTFPVGTEINLEVQDQTADTKADENWDFNDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQSGGTSMFFSEDSSSIEIQNQPLASGYYISTAPAPELPSWFWATCPSAKRHSPVHLKSSLHINISEVKNDDIAMESAKEKDKDKEKEEKDVHPLESRQTEEVLRHVLESYNALSWLNLNRQTGERYSCLPIHIQHLLRLYHSVARLLA
Length3017
PositionMiddle
OrganismCaenorhabditis latens
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.664
Instability index52.11
Isoelectric point6.06
Molecular weight341144.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14603
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     430.64|      94|     109|    1365|    1473|       1
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 1294- 1365 (90.72/35.04)	....YEPMVKRNF...ECP...PPRTfgvlaqkkrsgkraP.LPSSLPS.....TFSALNPGFA..NP....MGP..P........I..........................FQSPTLP.PHHIQSPF.SM...
 1366- 1473 (179.42/98.72)	GPMGHHPMGHPNY..PATPGPFPPTT..............PTYPGMTPR.....PGSNFGPGFG..YPN.QQMMP..PAYSNQMGSMGQmGQmgqmgqmgqMGPMgQlgvQRQFSNPQMY.QHQMQMRMQQMRQM
 1478- 1584 (160.50/69.21)	GPPGYGGPGVPPFqsPVTPGPGGFGM..............STGPSSVQRlnnfvNQSQFGPSSGqsYGSiPPMIPqsPNFNQPFPGMGN.AM.........MSPM.Q...QHQFHHQQMMqQHQQQHQHQQQHQL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     323.84|      99|     109|       2|     110|       2
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    2-  110 (158.55/140.12)	GRAWNDSGVVKCTFVTDNKIYSGPDVgGSIQLLVIDPgekPRPFHYD..WISTKKM....DDLLVLCKIAGAKEAHAPEKDkeKSSVGNV.MSTpkNISPVGFDQFVAlwYRHGKP
  113-  218 (165.28/112.44)	GRAWPKNGRIEASFVDSNREFTGATV.GSLQLLISLP...PTTVGYDyvWMAYGQAvdyrDKDYVPVHLSYICPAVVPVNG..KLILGQVnMKT..ECATVALDGTVT..QLDGGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     179.25|      41|     102|     531|     571|       3
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  467-  498 (27.95/10.66)	.....WNQWKEYLQ..LEEKE...PesvvEERQKSPDSEPTT......
  501-  524 (22.93/ 7.11)	PPAPRVLLASSSDE..EQPKSDG.N....DD.................
  531-  571 (74.96/43.87)	PQKFRWMYEPDYRQ..EKPKEET.P....EEREKRMQAREVRRIRRKN
  629-  669 (53.42/28.65)	PSKFICITVEEDRQmlESMGLKThP....PPQELQVQG...RRPRNKN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     546.80|     202|     656|     973|    1220|       4
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  973- 1210 (303.07/261.97)	QIKTARDCHLEMEKQLVKRS........LKRSLKKLRISAKKDSlSDPVIQEEELDPLL....LNRVDVKALDKSVKLMENELDQMNMNTFcinreKAGPhgVPSTSGFIPA.D..YTLSPHR..SFEEESDSEIDEQRTGLGEG.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tsdqyeegesvdmvepDREQIPDHSVDFANIGHIRTVGdhiGPDGLLSPPASNEMPKGGPLSVGpPSIESQglnqiyPTP..PSVQMLQENAAQGHSPVmmHGKSRYTANAS
 1621- 1757 (149.70/74.03)	QVNAAFNQLSDREKQKFNRRqiqllhgiMPTSLQPATIKALRNP.PDANIPFKKPDPIYrhpdLNIPRGDSLTIAIVLSDTLLDLHFDSVF.....DACP..ICSCSVSIRSrDlgMYITPHMvlSSRERGQTNMREYTVGTWSG.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2851- 2934 (94.02/38.22)	.................................................................................................................................................fhvnsatnctcgfsairhrylsccsglfeedadeattsehamapvipplnypkratgrdmtwfdsksvhdmallnqirqmafsnsigkavsqmasgaeharnvsiamdigtdvtvpseyilshvdtlellmlgmsalgpmqksgignqiasqnkflsyfhpwgfqtaneiteleasewvdllgivtptlevsmkharhlppeapttvegpmtwkqivtkairgkplsdddddysltepvpavmraltkeairaapnieqysdqaslgpidqpkdvmyitiipddptiyekavefmdnvtatyermrlgrhipfpvstgtatkfrkvleeqqnqfnfpekpaqpedeakkakdskdfedhfgrepveteldfwirrakrkfdsyedlkktedtdipppdsfdkemsknnvyrrrmsgfpfredryyeregilrvgtplersrlqhtvtntpefenmtrhlndkngfvtklrlylqqmedlvhhaltenaeafertgyryqlavegrlkrrkhrkdlneerlryesaklmedevliavqpeeadlctgvevgnegsvpwvndelqeqkelkqkeneqyppeghqapspvpagmihipetlskqertvqpslndifadpstvapmnaqniswkkrdthvpnpfpssnqppvafeatgsldtdaistlphvivlyvvnpfsygpeghsaihmriailafirafnsiigrlpfqkrpqlqleiigleslddvtksipdyfndpkvpfdilhdnqtkfertaeaeqaeiarslsvavythprvftpdvyksvsarcmtafgpgsqiintinniekinqdsffrmskrskmaletldgfrhpgmmapqqvekknyiayrvpsnilclappppvyqmdedgkpvlnqldeqtlfisyclvgadflvatatdaqgklidncvanikprrqrnqvyryrnktqildgmgklwsfilgvmssdiknwrlvvgrlgrighgefrawthllnktsllrysgslkdicsacrsmptavgtpailsaclitlepepsirimpdfqdqsattkksyifqtpgdlscthiltfpvgteinlevqdqtadtkadenwdfndldimeglddgDTEIMKDLGLETPSSAAIRQSG...GTSMFFSEDSSSIEIQNQPLASG.YYISTA......PAPelPSWFWATCPSAKRHSPV..HLKSSLHINIS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     206.60|      82|     656|    1891|    1992|       6
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 1891- 1952 (66.40/52.48)	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSALGPmqKSGIG.NQIASQNKF..LSYFHpwgfQTANEITELEASEWVDLLGIVTPTlEVSMKH
 1953- 1983 (14.21/21.14)	ARHLPPEAPTTVEGPMTWkQIVTKairGKPL.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2548- 2604 (76.32/38.33)	...............................sdddddysltepvpavmraltkeairaapnieqysdqaslgpidqpkdvmyitiipddptiyekavefmdnvtatyermrlgrhipfpvstgtatkfrkvleeqqnqfnfpekpaqpedeakkakdskdfedhfgrepveteldfwirrakrkfdsyedlkktedtdipppdsfdkemsknnvyrrrmsgfpfredryyeregilrvgtplersrlqhtvtntpefenmtrhlndkngfvtklrlylqqmedlvhhaltenaeafertgyryqlavegrlkrrkhrkdlneerlryesaklmedevliavqpeeadlctgvevgnegsvpwvndelqeqkelkqkeneqyppeghqapspvpagmihipetlskqertvqpslndifadpstvapmnaqniswkkrdthvpnpfpssnqppvafeatgsldtdaistlphvivlyvvnpfsygpeghsaihmriailafirafnsiigrlpfqkrpqlqleiigleslddvtksipdyfndpkvpfdilhdnqtkfertaeaeqaeiarslsvavythprvftpdvyksvsarcMTAFGP..GSQII.NTINNIEKInqDSFFR....MSKRSKMALETLDGFRHPGMMAPQ.QVEKKN
 2607- 2646 (49.67/22.87)	AYRVPSNILCLAPPPPVY.QMDED...GKPV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lNQLDEQTLF..ISY.....................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.59|      27|     102|     757|     783|       7
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  757-  783 (51.02/34.15)	AYLMSYRPR............VRSHM.P.TYDPKNDEETFN
  861-  883 (39.33/24.18)	ANLEDDHPK............V...I.P.EIEVEK.EELFN
  891-  931 (31.24/17.27)	PNDDTYKPKpffpvsllttvsSRSELiPlAGDDEMSEERFN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.10|      72|    1604|     338|     431|       8
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  240-  328 (107.16/80.54)	IPAGSGPARDSSEDMLSSKEGDkdalknklKNAKRPEFINGGSLEDCLS.....NVYSlLELPGIKWKCFRtkpnaprgVPLTSDLVLKAYSRC
  351-  427 (121.94/89.39)	LPATHFFSNDSPKELWVFWYDD........EPTDLPKLCEGLESDEELSsanqmNIVS.YEVRTLIFKALH........VVLERDLTKDGHFDC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.68|      30|    1604|     721|     750|       9
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  721-  750 (55.84/33.05)	KEKTDKKEKIEKAPSP....PPYELYKH.KESY..LS
 2947- 2983 (38.84/20.42)	KEKDKDKEKEEKDVHPlesrQTEEVLRHvLESYnaLS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.27|      18|     106|     684|     706|      11
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  574-  591 (29.45/11.41)	ERLKELERQRAETTNAED
  688-  705 (31.81/15.29)	ERQRMIDRERLNKENAHD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.97|      39|     426|    2050|    2088|      13
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 2050- 2088 (68.04/38.41)	EFMDNVTATYERMRLGRHIPFPVSTGTATKFRKVLEEQQ
 2479- 2517 (67.93/38.34)	ESLDDVTKSIPDYFNDPKVPFDILHDNQTKFERTAEAEQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14603 with Med13 domain of Kingdom Metazoa
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